ArticleiScience2026
Type I IFN-controlled Qa-2 expression identifies and maps the generation of Eomes
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Innate CD8 T cells are a subset of CD8 lineage T cells that acquire proinflammatory effector functions during their development in the thymus. Yet the developmental mechanisms diverting them from conventional CD8 T cells remain incompletely understood. By mapping their developmental trajectory in the thymus, here we identify high-level expression of the nonclassical MHC-I molecule Qa-2 as a surface marker of innate CD8 T cells. Because Qa-2 expression is induced by type I interferon (IFN) signaling, these results further led us to uncover a role for tonic type I IFN signaling in their generation. Accordingly, interleukin-4 is considered both necessary and sufficient for this process, but innate CD8 T cell differentiation was also markedly impaired in the absence of type I IFN signaling, as documented with genetically engineered mice. Altogether, these findings report an intrathymic cytokine circuitry that orchestrates the differentiation of innate CD8 T cells during their thymic development.
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