Location matters: Spatial-dependent effects of myofibroblasts modulate survival in breast cancer.

Hannah Si Hui Lau, Veronique Kiak Mien Tan, Ines Poljak, Anita Grigoriadis, Giulia Adriani, Kanaga Sabapathy

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hannah Si Hui LauDivisions of Cellular & Molecular Research, National Cancer Centre Singapore, Singapore 168583, Singapore.

Veronique Kiak Mien TanDivisions of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore 168583, Singapore.

Ines PoljakCentre for Craniofacial and Regenerative Biology, King's College London, London, UK.

Anita GrigoriadisCancer Bioinformatics, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Giulia AdrianiSingapore Immunology Network, Agency for Science, Technology and Research (A∗STAR), Singapore 138648, Singapore.

Kanaga SabapathyDivisions of Cellular & Molecular Research, National Cancer Centre Singapore, Singapore 168583, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While cancer-associated fibroblasts (CAFs) have been historically considered pro-tumorigenic, several studies found that myofibroblast-like CAFs (myCAFs) may have tumor-restraining properties. Here, we show that myofibroblasts exhibit location-dependent effects in breast cancer progression. Deconvolution of bulk RNA sequencing data from The Cancer Genome Atlas showed that high intratumoral myCAF abundance in ER

Indexed as

breast cancercancer-associated fibroblastsmyofibroblaststumor microenvironment

Identifiers

PMID42491584

DOI10.1016/j.isci.2026.116556

PMCPMC13378321

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.