ArticleiScience2026
Human-relevant transcranial magnetic stimulation in awake rhesus macaques assisted by a non-invasive head and arm fixation apparatus.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Stochastic Approximator of Motor Threshold (SAMT) for Transcranial Magnetic Stimulation: Online Software and Its Performance in Clinical Studies.Transcranial magnetic stimulation (2024) · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique widely employed in basic and clinical research. Non-human primates (NHPs) represent translationally valuable models due to their close anatomical and functional similarity to humans. However, significant technical challenges remain in implementing human-like TMS protocols in awake NHPs. Here, we developed a non-invasive head- and arm-fixation apparatus that enables reliable stimulation and electromyography recordings in awake NHPs without surgical intervention and validated the apparatus with two TMS protocols in rhesus macaques. First, we implemented an adaptive motor threshold (MT) determination method developed recently for humans, which converged successfully to valid MTs as defined by the International Federation of Clinical Neurophysiology. Second, we measured a robust short-interval intracortical inhibition effect for the first time in awake NHPs. Successful implementation of human TMS protocols in awake NHPs provides proof-of-concept validation of our apparatus, paving the way to bidirectionally translatable, clinically relevant neuromodulation protocols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.