ArticleCase reports in hepatology2026
Liver Injury Associated With Irregular Herbal Products: A Translational Case Series With Chemical Authentication and Causality Assessment Using the Updated RUCAM.
Article in Case reports in hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Herb-induced liver injury (HILI) represents an increasing diagnostic challenge owing to the widespread use of herbal and dietary supplements (HDS), which are frequently consumed without reliable information regarding their composition or safety. Mischaracterized products may obscure causal attributes and mimic primary herbal hepatotoxicity. Methods and Results: We report a case series of five patients with suspected HILI at a tertiary university hospital in Bahia, Brazil. Clinical causality was prospectively assessed using the updated Roussel Uclaf Causality Assessment Method (RUCAM, 2016). Most patients present with hepatocellular injury following exposure to commercially available HDS, frequently in the presence of metabolic comorbidities. Analytical authentication of the consumed products revealed substantial label-composition discordance, including negligible amounts of turmeric-derived constituents in a Conclusion: Product authentication may substantially improve the diagnostic accuracy of suspected HILI and reduce the etiological uncertainty. Incorporating the verification of consumed supplements into hepatology evaluation may help distinguish true herbal hepatotoxicity from adulteration-related liver injury, thereby improving patient safety and pharmacovigilance.
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