ReviewFrontiers in pediatrics2026
Maternal, healthcare, and nutritional factors influencing birth defects in China from 2019 to 2025: a systematic review and meta-analysis.
Review in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Objective: This study aims to systematically evaluate the primary influencing factors of birth defects in China from 2019 to 2025, providing evidence for decision-making and intervention measures in the prevention of birth defects. Methods: A comprehensive search was conducted in various databases, including CNKI, Wanfang, VIP, China Biomedical Literature Database, PubMed, Web of Science, Embase, Elsevier Science Direct, and CINAHL, covering literature published from January 2019 to December 2025. Two researchers independently performed literature screening, quality assessment, and data extraction. Meta-analysis was conducted using Stata 17.0 software. For factors exhibiting high heterogeneity ( Results: A total of 25 studies were included in this analysis, comprising 26,019 cases of birth defects. Seventeen influencing factors were identified. Maternal physiological factors included maternal age ≥35 years (OR = 1.26, 95% CI: 1.05-1.47), maternal BMI > 30 kg/m Conclusion: Numerous factors influence the occurrence of birth defects. Medical professionals should prioritize addressing irregular folic acid supplementation, low rates of premarital examinations, and regional disparities in prenatal care as key intervention targets in China. It is essential to implement targeted interventions on controllable factors to prevent and reduce the incidence of birth defects.
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