Evidence map›Paper›PMID 42491488›Full record

ArticleMedComm2026

Genetically Engineered Probiotic Nanoplatform for Ultrasound-Enhanced Colorectal Cancer Therapy via Targeted Delivery, Immune Modulation, and Anti-Angiogenesis.

Jie Long, Tongrui Shang, Xuezhong Mo, Yunfang Yu, Feng Lin, Zixuan Liang, Olivia Monteiro, Daniel Baptista-Hon, Dominic Chi-Chung Foo, Lui Ng and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jie LongDepartment of Otolaryngology-Head and Neck Surgery, Colorectal and Anal Disease Unit, Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer Guangxi Medical University Cancer Hospital Nanning China.
Tongrui ShangGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA Medicine Sun Yat-sen Memorial Hospital, Sun Yat-sen University Guangzhou China.
Xuezhong MoDepartment of Otolaryngology-Head and Neck Surgery, Colorectal and Anal Disease Unit, Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer Guangxi Medical University Cancer Hospital Nanning China.
Yunfang YuGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA Medicine Sun Yat-sen Memorial Hospital, Sun Yat-sen University Guangzhou China.ORCID https://orcid.org/0000-0003-2579-6220
Feng LinDepartment of Otolaryngology-Head and Neck Surgery, Colorectal and Anal Disease Unit, Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer Guangxi Medical University Cancer Hospital Nanning China.
Zixuan LiangDepartment of Otolaryngology-Head and Neck Surgery, Colorectal and Anal Disease Unit, Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer Guangxi Medical University Cancer Hospital Nanning China.
Olivia MonteiroGuangdong Provincial Key Laboratory of Cancer Pathogenesis and Precision Diagnosis and Treatment, AI Big Data Laboratory, Shenshan Medical Center Memorial Hospital of Sun Yat-Sen University Shanwei China.
Daniel Baptista-HonGuangdong Provincial Key Laboratory of Cancer Pathogenesis and Precision Diagnosis and Treatment, AI Big Data Laboratory, Shenshan Medical Center Memorial Hospital of Sun Yat-Sen University Shanwei China.
Dominic Chi-Chung FooDepartment of Surgery University of Hong Kong Hong Kong, SAR China.
Lui NgDepartment of Surgery University of Hong Kong Hong Kong, SAR China.
Renchuan LiangDepartment of Otolaryngology-Head and Neck Surgery, Colorectal and Anal Disease Unit, Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer Guangxi Medical University Cancer Hospital Nanning China.
Man TongSchool of Biomedical Sciences The Chinese University of Hong Kong Hong Kong SAR China.
Weizhong TangDepartment of Otolaryngology-Head and Neck Surgery, Colorectal and Anal Disease Unit, Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer Guangxi Medical University Cancer Hospital Nanning China.
Kang ZhangArtificial Intelligence Cross Disciplinary Research Institute, Faculty of Medicine, Faculty of Innovation Engineering, School of Computer Science and Engineering Macau University of Science and Technology Macau China.
Yunxi HuangDepartment of Otolaryngology-Head and Neck Surgery, Colorectal and Anal Disease Unit, Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer Guangxi Medical University Cancer Hospital Nanning China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, largely due to limitations in early diagnosis and effective treatment. To address these challenges, we developed a multifunctional probiotic nanoplatform, EcNA@Cur-Lip-FA, that integrates real-time diagnosis, targeted therapy, and immune modulation for enhanced CRC treatment. Specifically, this system leverages genetically engineered

Indexed as

acoustic reporter geneschinese medicine curcumincolorectal cancerEscherichia coli Nissle 1917tumor microenvironment

Identifiers

PMID42491488
PMCPMC13376840

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.