Diamine Oxidase Supplementation for Histamine Regulation in Constipation-Predominant Irritable Bowel Syndrome: A Case Report.

Cari Pierce, Oscar Coetzee

Abstract readCase Reports

In one paragraph

Article in Integrative medicine (Encinitas, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cari PierceClinical Director, Natural Healthcare Center, Long Branch, New Jersey, USA; Professor, Notre Dame of Maryland University, Baltimore, Maryland, USA; Associate Adjunct Professor, Georgetown University, Washington, DC, USA.

Oscar CoetzeeClinical Director, Natural Healthcare Center, Long Branch, New Jersey, USA; Professor, Notre Dame of Maryland University, Baltimore, Maryland, USA; Associate Adjunct Professor, Georgetown University, Washington, DC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since 2016, irritable bowel syndrome has been defined by a grouping of primary symptoms and no longer requires invasive testing for diagnosis. Abdominal pain related to bowel movements or relieved by having a bowel movement is the primary symptom of this functional gastrointestinal disorder. Through expanding appreciation of functional gastrointestinal disorders and the increasing understanding of gastrointestinal tract-brain interactions, a growing body of research is discussing the symptom overlap between IBS and histamine intolerance, as well as other issues of histamine metabolism and related neuroimmune regulation in the pathophysiology of IBS. Visceral hypersensitivity, exacerbated by increased histamine levels, may disrupt the intricate signaling between the central nervous system and enteric nervous system. This case report illustrates the use of supplemental diamine oxidase combined with trigger food avoidance to nearly completely abate IBS symptoms in a 46-year-old Japanese American female.

Indexed as

case reportconstipationdiamine oxidaseHistaGest-DAOhistamine metabolismirritable bowel syndromeSymptom Severity Score

Identifiers

PMID42491458

PMCPMC13377774

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.