ArticleACS environmental Au2026
Bioaccumulation Dynamics of Metal Ions and Complexes by Aquatic Organisms: An Extended Best and Michaelis-Menten Framework for the Interplay between Chemodynamics, Bioavailability, and Biouptake Kinetics.
Article in ACS environmental Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
This study elaborates a theoretical framework to understand metal bioaccumulation beyond the limitations of the equilibrium-based Biotic Ligand Model (BLM). By integrating the dynamics of metal speciation in aquatic media with the kinetics of metal biouptake, the formalism predicts metal bioavailability under conditions where the BLM fails, such as high degrees of metal complexation, diffusion-limited metal uptake, and/or internalization of intact metal complexes. The theory accounts for the reactive transport of free metal ions and complexes, incorporating different uptake mechanisms by facilitated and passive diffusion. Extended Best expressions are derived for the flux of metal biouptake by coupling extracellular metal chemodynamics (intertwined diffusion and complexation) with Michaelis-Menten uptake kinetics. The approach provides a unified rationale for various bioaccumulation situations, including the uptake of lipophilic complexes, and the concomitant uptake of free and complexed metals through distinct or shared diffusion-facilitated pathways with competitive, noncompetitive, and/or uncompetitive inhibitions. Computational examples are detailed to illustrate the intricate interplay between metal species transport dynamics and biouptake kinetics for all bioaccumulation cases, particularly addressing how the metal internalization flux is impacted by the (bioavai)-lability of metal complexes, whether or not they are internalized intact. The benefits of the formalism are further illustrated through an analysis of well-characterized experimental data on neodymium (Nd) uptake by
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