Evidence map›Paper›PMID 42491336›Full record

ArticleMedComm2026

Targeting the NAT1-ENO1-Lactate Axis Destabilizes PD-L1 to Reinvigorate Antitumor Immunity in Colorectal Cancer.

Yi-Xuan Liu, Wen-Xin Wu, Yang Zang, Guang Hu, Xin Guo, Yi Wang, Yun Yang, Zhi Jiang, Xiu-Ming Li, Feng Liu and 9 more

Abstract read
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yi-Xuan LiuDepartment of Pathology The Fourth Affiliated Hospital of Soochow University Suzhou Medical College of Soochow University Soochow University Suzhou Jiangsu China.
Wen-Xin WuDepartment of Pathology The Fourth Affiliated Hospital of Soochow University Suzhou Medical College of Soochow University Soochow University Suzhou Jiangsu China.
Yang ZangMedical College, Yangzhou University Yangzhou Jiangsu China.
Guang HuDepartment of Bioinformatics School of Life Science Soochow University Suzhou Jiangsu China.
Xin GuoDepartment of Pathology The Fourth Affiliated Hospital of Soochow University Suzhou Medical College of Soochow University Soochow University Suzhou Jiangsu China.
Yi WangDepartment of Pathology The Fourth Affiliated Hospital of Soochow University Suzhou Medical College of Soochow University Soochow University Suzhou Jiangsu China.
Yun YangDepartment of Pathology The Fourth Affiliated Hospital of Soochow University Suzhou Medical College of Soochow University Soochow University Suzhou Jiangsu China.
Zhi JiangNational Center of Technology Innovation for Biopharmaceuticals Suzhou Biomedical Industry Innovation Center Suzhou Jiangsu China.
Xiu-Ming LiDepartment of Pathology The First Affiliated Hospital of Soochow University Suzhou Jiangsu China.
Feng LiuDepartment of General Surgery Suzhou Guangci Cancer Hospital Suzhou Jiangsu China.
Yue-Yue WuDepartment of Pathology The Fourth Affiliated Hospital of Soochow University Suzhou Medical College of Soochow University Soochow University Suzhou Jiangsu China.
Zu-Da PanDepartment of Pathology The Fourth Affiliated Hospital of Soochow University Suzhou Medical College of Soochow University Soochow University Suzhou Jiangsu China.
Yuan-Meng HuDepartment of Pathology The Fourth Affiliated Hospital of Soochow University Suzhou Medical College of Soochow University Soochow University Suzhou Jiangsu China.
Ruo-Yang ZhangDepartment of Pathology The Fourth Affiliated Hospital of Soochow University Suzhou Medical College of Soochow University Soochow University Suzhou Jiangsu China.
Hai-Yi ZhangDepartment of Pathology The Fourth Affiliated Hospital of Soochow University Suzhou Medical College of Soochow University Soochow University Suzhou Jiangsu China.
Ping-An ChangDepartment of Urology Surgery Affiliated Dongtai Hospital of Nantong University Dongtai Jiangsu China.
Xiao-Shun HeDepartment of Pathology The First Affiliated Hospital of Soochow University Suzhou Jiangsu China.
Wen-Juan GanDepartment of Pathology The Fourth Affiliated Hospital of Soochow University Suzhou Medical College of Soochow University Soochow University Suzhou Jiangsu China.
Hua WuDepartment of Pathology The Fourth Affiliated Hospital of Soochow University Suzhou Medical College of Soochow University Soochow University Suzhou Jiangsu China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic dysregulation is a hallmark of tumorigenesis and profoundly impacts immune surveillance; however, the underlying mechanisms and targeted treatments remain limited in colorectal cancer (CRC). Here, we utilize public databases, mouse models, and multi-omics analyses to identify

Indexed as

acetylationcolorectal cancerglycolysisimmunotherapyN‐acetyltransferase 1 (NAT1)TNF receptor‐associated factor 6 (TRAF6)

Identifiers

PMID42491336
PMCPMC13376828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.