Evidence map›Paper›PMID 42491259›Full record

ArticleFrontiers in pharmacology2026

Linalyl acetate alleviates inflammatory pain via OLFR482 activation in the mouse anterior cingulate cortex.

Ban Feng, Wei Guo, Shu Zhao, Han Wang, Xinshang Wang, Kun Zhang, Dake Song, Peng Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ban Feng *Shanghai Key Laboratory of Anaesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Department of Anaesthesiology and Perioperative Medicine, Clinical Research Center for Anaesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Wei Guo *Department of Pediatrics, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Shu Zhao *Shanghai Key Laboratory of Anaesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Department of Anaesthesiology and Perioperative Medicine, Clinical Research Center for Anaesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Han WangShanghai Key Laboratory of Anaesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Department of Anaesthesiology and Perioperative Medicine, Clinical Research Center for Anaesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Xinshang WangDepartment of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Kun ZhangDepartment of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Dake SongDepartment of Pediatrics, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Peng GaoShanghai Key Laboratory of Anaesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Department of Anaesthesiology and Perioperative Medicine, Clinical Research Center for Anaesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Chronic pain severely impairs quality of life and causes heavy socioeconomic burdens worldwide. Linalyl acetate (LA), a major volatile terpenoid ester from essential oils, possesses potential analgesic effects. Methods: A CFA-induced chronic inflammatory pain mouse model was established. Behavioral tests, immunofluorescence, whole-cell patch-clamp recording, RNA-seq, molecular docking, molecular dynamics simulation and AAV-mediated gene knockdown were applied to explore the analgesic mechanism of LA. Results: Systemic LA administration significantly alleviated inflammatory pain and suppressed neuronal hyperexcitability in the anterior cingulate cortex (ACC). Transcriptome analysis revealed marked upregulation of Olfr482 in the ACC of CFA-treated mice, and molecular docking confirmed the interaction between LA and OLFR482. Olfr482 knockdown largely abolished the analgesic effect of LA. Discussion: LA relieves chronic inflammatory pain via an olfactory-independent mechanism by activating OLFR482 and reducing neuronal hyperexcitability in the ACC. LA is a promising candidate for developing novel analgesic drugs.

Indexed as

anterior cingulate cortexchronic inflammatory painlinalyl acetateneuronal excitabilityolfactory receptors

Identifiers

PMID42491259
PMCPMC13376266

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.