Evidence map›Paper›PMID 42491232›Full record

ReviewIMA fungus2026

Autophagy as a multi-scale architect of fungal development and pathogenicity: membrane dynamics, multilayer regulation, and cell wall integrity crosstalk.

Feixiang Wang, Jiarui Li, Huojuan Chen, Qiangwang Zheng, Tao Wei, Kun Feng, Bai-Xiong Chen

Abstract readReview
In one paragraph

Review in IMA fungus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Feixiang WangSchool of Bioengineering, Zunyi Medical University, Jinwan Road No. 368, Zhuhai 519090, Guangdong, China Institute of Food Biotechnology & College of Food Science, South China Agricultural University Guangzhou China https://ror.org/05v9jqt67.
Jiarui LiSchool of Bioengineering, Zunyi Medical University, Jinwan Road No. 368, Zhuhai 519090, Guangdong, China Institute of Food Biotechnology & College of Food Science, South China Agricultural University Guangzhou China https://ror.org/05v9jqt67.
Huojuan ChenSchool of Bioengineering, Zunyi Medical University, Jinwan Road No. 368, Zhuhai 519090, Guangdong, China Institute of Food Biotechnology & College of Food Science, South China Agricultural University Guangzhou China https://ror.org/05v9jqt67.
Qiangwang ZhengInstitute of Food Biotechnology & College of Food Science, South China Agricultural University, Guangzhou 510642, Guangdong, China School of Bioengineering, Zunyi Medical University Zhuhai China.ORCID https://orcid.org/0000-0001-8640-4513
Tao WeiInstitute of Food Biotechnology & College of Food Science, South China Agricultural University, Guangzhou 510642, Guangdong, China School of Bioengineering, Zunyi Medical University Zhuhai China.ORCID https://orcid.org/0000-0003-3816-8127
Kun FengSchool of Bioengineering, Zunyi Medical University, Jinwan Road No. 368, Zhuhai 519090, Guangdong, China Institute of Food Biotechnology & College of Food Science, South China Agricultural University Guangzhou China https://ror.org/05v9jqt67.ORCID https://orcid.org/0000-0002-2828-8232
Bai-Xiong ChenSchool of Bioengineering, Zunyi Medical University, Jinwan Road No. 368, Zhuhai 519090, Guangdong, China Institute of Food Biotechnology & College of Food Science, South China Agricultural University Guangzhou China https://ror.org/05v9jqt67.ORCID https://orcid.org/0000-0003-0934-083X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy is a conserved membrane-trafficking pathway traditionally viewed as a nonspecific nutrient recycling mechanism. However, recent advances across diverse fungal systems, from plant pathogens to human opportunistic fungi and entomopathogenic species, have revealed autophagy as a central regulatory hub that orchestrates fungal development, virulence, and host interaction at multiple biological scales. This review provides a comprehensive and critical synthesis of these emerging insights. At the nanoscale, the discussion explores how autophagosome biogenesis depends on the spatially precise delivery of PtdIns4P by oxysterol-binding proteins, the dual function of the TRAPPIII vesicle-tethering complex, and the retromer-mediated sorting of vacuolar proteases. At the organelle level, the interplay between selective autophagy (mitophagy, lipophagy, pexophagy) and a newly discovered layer of epitranscriptomic, transcriptional, and post-translational regulation, comprising m

Indexed as

Cell wall integrityentomopathogenic fungiepitranscriptomic regulationfungal autophagyhost-pathogen interactionsmorphogenesis

Identifiers

PMID42491232
PMCPMC13377003

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.