Evidence map›Paper›PMID 42491188›Full record

ArticleAmerican journal of translational research2026

WSB1 is dispensable for mouse spermatogenesis and male fertility.

Wenying Qu, Xiaochu Wang, Shiqi Liu, Nianchao Zhou, Cong Shen, Ruiqing Tong, Xiangxiang Xu

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Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Wenying QuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University Suzhou 215002, Jiangsu, China.
Xiaochu WangState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University Suzhou 215002, Jiangsu, China.
Shiqi LiuDepartment of Thyroid and Breast Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University Suzhou 215002, Jiangsu, China.
Nianchao ZhouState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University Suzhou 215002, Jiangsu, China.
Cong ShenState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University Suzhou 215002, Jiangsu, China.
Ruiqing TongCenter for Reproduction, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital) Suzhou 215124, Jiangsu, China.
Xiangxiang XuDepartment of Obstetrics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University Suzhou 215002, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposesWSB1 (WD repeat and SOCS box-containing protein 1) is part of the E3 ligase complex Elongin B/C-Cullin 2/5-SOCS box E3 ubiquitin ligase (ESC) complex. Our previous studies and those of others have confirmed that some SOCS box proteins, including ASB1 and ASB9, are important for the development of male germ cells. Given that WSB1 is a member of the same protein family, we hypothesized that it might also be involved in spermatogenesis. Although WSB1 has been implicated in tumorigenesis and cancer progression in other tissues due to its E3 ligase activity, its roles and mechanisms in spermatogenesis remain unknown.

methodsConditional knockout (cKO) mice with deletion of the

findingsCompared with wild-type (WT) mice,

Indexed as

E3-ubiquitin ligasemale fertilityspermatogenesisWSB1

Identifiers

PMID42491188
PMCPMC13376040

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