ArticleAmerican journal of translational research2026
Evidence for platelet-rich fibrin in combination with other regenerative materials for treatment of periodontal furcation defects: a systematic review and meta-analysis.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
This study aimed to examine the effects of platelet-rich fibrin (PRF), alone or in combination with other regenerative materials, for periodontal furcation defects and to evaluate the quality of existing evidence. A systematic search was performed for studies published up to October 2025 in several databases, such as PubMed/MEDLINE, Embase, Scopus, and Cochrane Central Register of Controlled Trials. This meta-analysis included only randomized controlled trials (RCTs) that used PRF for Class II furcation defects with a follow-up period of more than 6 months. Main outcomes included probing depth (PD) and clinical attachment level (CAL), while secondary outcomes included radiographic bone fill. Twenty RCTs involving 786 participants were included. The use of PRF with open flap debridement (OFD) significantly improved PD reduction, vertical CAL gain, and horizontal CAL gain compared to OFD alone (P < 0.00001). PRF combined with bone grafts (BG) yielded comparable or slightly superior clinical outcomes to BG alone. The adjunctive use of small biomolecules with PRF demonstrated significant additional benefits in improving clinical findings compared to PRF monotherapy. The evidence was characterized by a high heterogeneity (I
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