ArticleAmerican journal of translational research2026
Efficacy of nimodipine plus mannitol in the treatment of cerebral edema after intracerebral hemorrhage and its impact on cerebral hemodynamic parameters.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveCerebral edema (CE) following intracerebral hemorrhage (ICH) remains a therapeutic challenge. This study aimed to evaluate the clinical effectiveness of nimodipine combined with mannitol for post-ICH CE.
methodsA total of 220 patients with post-ICH CE were retrospectively included in this study. Patients were assigned to either a control group receiving nimodipine monotherapy (n=101) or a study group receiving nimodipine plus mannitol (n=119). Therapeutic response, hematoma/edema volume, intracranial pressure (ICP), National Institutes of Health Stroke Scale (NIHSS) score, cerebral hemodynamic parameters, and adverse events were compared between the groups. Logistic regression analysis was performed to identify factors related to favorable outcomes.
resultsA notably higher overall response rate was observed in the study group (86.55%) compared to the control group (69.31%) (P=0.002). Patients in the study group showed greater reductions in terms of hematoma and edema volumes, more pronounced improvements in ICP, NIHSS scores, and cerebral hemodynamics (all P < 0.05). Logistic regression identified combination therapy, larger initial cerebral edema volume, and higher baseline NIHSS score as factors related to favorable outcomes. No significant inter-group difference was noted in the incidence of adverse events (P > 0.05).
conclusionIn patients with CE secondary to ICH, nimodipine combined with mannitol is more effective than nimodipine alone in improving clinical outcomes and cerebral hemodynamics.
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