ArticleJournal of pharmaceutical analysis2026
h3B7A-LDM, a novel anti-mesothelin antibody-drug conjugate with the potential to induce antitumor immunity, shows potent efficacy against solid tumors.
Article in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Antibody-drug conjugates (ADCs) are a promising class of cancer therapeutics that enable the targeted delivery of highly cytotoxic payloads to cancer cells. Mesothelin (MSLN) is an attractive therapeutic target in cancer treatment. Lidamycin (LDM), an enediyne-containing antibiotic with potent antitumor effects, has potential as ADC payload. To generate an ADC targeting MSLN, we first produced a novel anti-MSLN antibody, 3B7A, using hybridoma technology. We then obtained the humanized version, h3B7A, via complementarity-determining region (CDR) grafting. This was followed by fusion with LDM through genetic recombination and molecular assembly to create the ADC h3B7A-LDM. h3B7A-LDM undergoes efficient internalization and lysosomal trafficking in MSLN-positive cancer cells. It demonstrates strong tumor-targeting capability and long-term persistence in tumor-bearing mice.
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