Evidence map›Paper›PMID 42491045›Full record

ArticleAmerican journal of translational research2026

Improvement of wound healing after diabetic foot debridement by a novel high ankle block: a randomized controlled trial.

Kai Wang, Guang-Kuo Ma, Teng Jiang, Huan-Jia Xue, Zi-Wei Xia, Tong Wang, Mao-Sheng He, Ming-Ling Wang, Su Feng, Jian Cui and 1 more

Registry-linked trialAbstract read
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In one paragraph

Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06395961 (Effect of New High Ankle Block on Wound Healing After the Operation of Debridement of Diabetes Foot), which is not on this map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06395961 naunknown statusnot on this map

Effect of New High Ankle Block on Wound Healing After the Operation of Debridement of Diabetes Foot

TypeinterventionalSponsorXuzhou Central HospitalRan2023 to 2025Enrolled70ConditionsWound Heal, Diabetic Foot UlcerArmshigh ankle block, general anesthesia
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kai WangDepartment of Anesthesiology, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou Central Hospital Xuzhou 221009, Jiangsu, China.
Guang-Kuo MaDepartment of Anesthesiology, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou Central Hospital Xuzhou 221009, Jiangsu, China.
Teng JiangDepartment of Anesthesiology, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou Central Hospital Xuzhou 221009, Jiangsu, China.
Huan-Jia XueDepartment of Anesthesiology, Xi'an Hospital of Traditional Chinese Medicine Xi'an 710000, Shaanxi, China.
Zi-Wei XiaDepartment of Anesthesiology, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou Central Hospital Xuzhou 221009, Jiangsu, China.
Tong WangDepartment of Anesthesiology, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou Central Hospital Xuzhou 221009, Jiangsu, China.
Mao-Sheng HeDepartment of Ultrasound, Xuzhou Central Hospital Xuzhou 221009, Jiangsu, China.
Ming-Ling WangOperating Room, Xuzhou Central Hospital Xuzhou 221009, Jiangsu, China.
Su FengDepartment of Vascular Surgery, Xuzhou Central Hospital Xuzhou 221009, Jiangsu, China.
Jian CuiDepartment of Anesthesiology, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou Central Hospital Xuzhou 221009, Jiangsu, China.
Li-Wei WangDepartment of Anesthesiology, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou Central Hospital Xuzhou 221009, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the effect of ultrasound-guided high ankle block (HAB) on postoperative wound healing and foot perfusion after diabetic foot debridement.

methodsThis prospective, assessor-blinded randomized controlled trial (NCT06395961) enrolled 70 patients with Wagner II-IV diabetic foot ulcers undergoing debridement. Thirty-five patients received HAB with 35 mL of 0.375% ropivacaine, and 35 received general anesthesia (GA). The primary outcome was ulcer area on postoperative day 7, measured using ImageJ boundary delineation. Ulcer area was also assessed on days 1, 7, 14, 28, and 60. Secondary outcomes included: anterior and posterior tibial artery hemodynamics assessed by Doppler ultrasound on days 1, 7, and 14; foot skin temperature measured by infrared thermography on days 2, 4, 6, 8, 10, 12, and 14 (to avoid interference with ultrasound measurement); and visual analog scale (VAS) pain scores, opioid consumption, and adverse events assessed at various time points.

resultsThe HAB group showed significantly higher ulcer healing rates on day 7 (42.2% vs. 29.4%,

conclusionHAB enhances foot perfusion, accelerates early ulcer healing, and provides superior analgesia with fewer complications compared with GA.

Indexed as

diabetic footHigh ankle blocknerve blockpostoperative painulcerwound healing

Identifiers

PMID42491045
PMCPMC13376024

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Registered trials

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