ArticleAmerican journal of translational research2026
Correlation between perioperative red blood cell transfusion strategy and 3-month neurological outcomes in patients undergoing craniotomy for traumatic brain injury.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the correlation between perioperative red blood cell (RBC) transfusion trigger thresholds and 3-month neurological outcomes in patients undergoing craniotomy for traumatic brain injury (TBI).
methodsA total of 113 patients were retrospectively enrolled and stratified into two groups according to hemoglobin (Hb) level: a restrictive transfusion group (Hb < 80 g/L) and an liberal transfusion group (Hb < 90 g/L). Transfusion exposure and clinical outcomes were compared between the two groups, and multivariate logistic regression as well as inverse probability of treatment weighting (IPTW) were adopted for statistical analysis.
resultsThe restrictive group had lower transfusion rate and transfusion volume (both P < 0.05). The incidence of adverse neurological functional outcomes (defined as Glasgow Outcome Scale-Extended score, GOSE score ≤ 4) at 3 months postoperatively was lower in the restrictive group. Multivariate logistic regression analysis indicated that the restrictive transfusion strategy was marginally associated with a lower risk of adverse outcomes (OR=0.40, P=0.053). The IPTW analysis yielded a consistent trend without statistical significance (P=0.110). There was no statistically significant difference in the incidence of complications.
conclusionThe restrictive transfusion strategy can reduce transfusion exposure and is correlated with a favorable trend in neurological functional prognosis. Further studies are still required to validate these findings.
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