ReviewFrontiers in physiology2026
Toward a gut-AMPK axis: the microbiome and AMPK signaling in nutrition and healthy aging.
Review in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Modern nutrition research has evolved from early discoveries of essential vitamins to exploring the complex interactions between a much larger range of food-derived compounds (the foodome). The microbiome is a key link between diet and health outcomes through multiple gut-host axes. However, the field lacks a unifying framework to demystify its inherent complexities. This review outlines mechanistic evidence that the 5'-AMP-activated protein kinase (AMPK) is a potential mediator of host-microbe relationships and helps move towards the concept of a gut-AMPK axis. Further, it suggests that a plausible function of a "healthy" gut microbiome is to increase the bioavailability of metabolites capable of modulating AMPK. These insights can facilitate larger efforts to define what constitutes a functional gut microbiome, understand the health effects of the broader foodome, and support organismal resilience and healthy aging.
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