SynthesisFrontiers in dental medicine2026
Clinical and radiographic outcomes of Aloe vera as a pulpotomy medicament in primary teeth: a systematic review.
Synthesis in Frontiers in dental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Introduction: Pulpotomy is a common vital pulp therapy in primary molars aimed at preserving radicular pulp vitality until exfoliation. Concerns regarding the cytotoxicity and systemic effects of formocresol have prompted interest in biocompatible alternatives such as Aloe vera, which possesses anti-inflammatory, antimicrobial, and regenerative properties. Aim: To evaluate the clinical and radiographic success of Aloe vera as a pulpotomy medicament in primary molars compared to conventional agents. Methods: A systematic search of PubMed, Scopus and Web of Science was conducted in accordance with PRISMA guidelines. Randomized controlled trials evaluating Aloe vera as a pulpotomy medicament in primary molars were included. Risk of bias was assessed using the Cochrane RoB2 tool, and the certainty of evidence for primary outcomes was evaluated using the GRADE approach. Results: Clinical success at 3-6 months was high (90%-100%) and comparable between groups. However, radiographic success was highly inconsistent; two major trials reported significantly lower success for Aloe vera (21.1% and 54.8%) compared to formocresol at 6-12 months. Conclusion: Aloe vera demonstrates promising short-term clinical performance, but it showed less predictable radiographic outcomes and was inferior to standard comparators in some trials. Due to the Very Low certainty of evidence and high risk of bias in major studies, herbal agents cannot currently be recommended as definitive substitutes for formocresol or MTA. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251230179, PROSPERO, identifier CRD420251230179.
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