ArticleFrontiers in cellular and infection microbiology2026
Acute and long-term effects of ocular surface burns on ocular surface microbiota: a one-year follow-up study.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Ocular surface burns (OSBs) are severe injuries that disrupt the ocular surface microenvironment. While the role of microbiota in ocular surface homeostasis is increasingly recognized, the acute and long-term impacts of OSB on this microbial community remain poorly understood. Methods: This longitudinal study collected conjunctival swabs from the inferior fornix of three groups: healthy controls (HOS, Results: Exploratory observations suggest trends toward altered ocular surface microbiota in OSB patients that may persist for at least one year. Alpha diversity was lower in OSB and OSB_1Y compared with HOS. At the genus level, Conclusion: OSB may be associated with acute and long-lasting changes in the ocular surface microbiota. Given the low-biomass nature of the ocular surface, the absence of formal contamination controls, the use of a stool-optimized DNA extraction kit, and the lack of multiple testing correction, these findings should be interpreted with extreme caution. These preliminary microbial observations appear nominally associated with some clinical parameters, which may provide exploratory clues for post-burn ocular surface changes, but no definitive pathophysiological relevance can be established.
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