ArticleWorld journal of oncology2026
Hypoxia-Induced Exosomal miR-1225-5p Accelerates Colorectal Cancer Progression by Targeting Carboxypeptidase M.
Article in World journal of oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Colorectal cancer (CRC) remains a considerable public health burden worldwide, with hypoxia emerging as a key driver of tumor aggressiveness. Within the hypoxic tumor microenvironment (TME), exosomes function as vital vehicles for intercellular communication, especially through their cargo of microRNAs (miRNAs). Despite the growing recognition of this phenomenon, the specific functions of hypoxia-induced exosomal miRNAs in CRC remain inadequately defined. Methods: Human CRC cell lines (SW620 and HCT116) were subjected to normoxic or hypoxic conditions. Exosomes were isolated via ultracentrifugation and rigorously characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS). Quantitative real-time PCR (qRT-PCR) profiling identified miR-1225-5p as significantly enriched under hypoxia. The uptake of Cy3-labeled miR-1225-5p-loaded and PKH67-labeled exosomes by CRC cells was confirmed. The impact of these phenomena on cell progression capabilities was subsequently evaluated through the implementation of cell counting kit-8, colony formation, Transwell invasion, and wound-healing assays. The validation of the miR-1225-5p-carboxypeptidase M ( Results: Hypoxic CRC cell-derived exosomes exhibited markedly increased miR-1225-5p content. These exosomes effectively transferred miR-1225-5p to recipient CRC cells, thereby enhancing their malignant behaviors. Mechanistically, miR-1225-5p directly suppressed Conclusion: The present study identifies a novel hypoxia-driven exosome-mediated miRNA pathway, whereby miR-1225-5p promotes CRC progression through targeted inhibition of the tumor suppressor gene,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.