ArticleAngewandte Chemie (International ed. in English)2026
Exclusive Hydroformylation of Terminal Olefins: A Phosphorus-Free Ruthenium System for the Selective Functionalization of Complex Mixtures.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We report a paradigm shift in ruthenium-catalyzed hydroformylation using a remarkably simple, phosphorus-free system based on ruthenium carbonyl complexes and DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). The optimal catalytic system operates under mild conditions and exhibits an unprecedented "terminal-only" selectivity. It quantitatively discriminates between terminal and internal or multi-substituted double bonds, which has been a long-standing challenge in oxo synthesis. Traditional systems often trigger the isomerization of internal olefins, but our catalyst leaves them untouched, even within complex industrial feedstocks. Comprehensive mechanistic investigations, including in situ IR spectroscopy and high-pressure VT NMR spectroscopy, identify the tetranuclear ruthenium-hydride cluster [DBUH]
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