Evidence map›Paper›PMID 42490685›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Sustainable Fabrication of Tailored Bone Substitutes: From High-Throughput Scaffold Manufacturing, Scaled-Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor.

Franziska Braun, Anna Paříková, Sandra Rother, Martin Kantor, Salman Muhammad Ilyas, Ricardo Bernhardt, Pavel Ndjawa Yomi, Jaromír Havlica, Revathi Appali, Benjamin Kruppke and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Franziska BraunInstitute of Materials Science, Max Bergmann Center of Biomaterials, TUD Dresden University of Technology, Dresden, Germany.
Anna PaříkováInstitute of Chemical Process Fundamentals, The Czech Academy of Sciences, Prague, Czech Republic.ORCID https://orcid.org/0000-0001-7098-0305
Sandra RotherInstitute of Biophysics, Center of Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany.
Martin KantorInstitute of Machines and Power Engineering, Faculty of Mechanical Engineering, University J.E. Purkyně, Ústí nad Labem, Czech Republic.ORCID https://orcid.org/0000-0001-7743-7372
Salman Muhammad IlyasInstitute of Materials Science, Max Bergmann Center of Biomaterials, TUD Dresden University of Technology, Dresden, Germany.
Ricardo BernhardtDepartment Materials Engineering, Institute of Polymers Materials, Leibniz-Institut Für Polymerforschung Dresden e.V. (IPF), Dresden, Germany.
Pavel Ndjawa YomiInstitute of General Electrical Engineering, Faculty of Computer Science and Electrical Engineering, University of Rostock, Rostock, Germany.
Jaromír HavlicaInstitute of Chemical Process Fundamentals, The Czech Academy of Sciences, Prague, Czech Republic.ORCID https://orcid.org/0000-0003-4750-4436
Revathi AppaliInstitute of General Electrical Engineering, Faculty of Computer Science and Electrical Engineering, University of Rostock, Rostock, Germany.
Benjamin KruppkeInstitute For Organic and Macromolecular Chemistry, Friedrich Schiller University Jena, Jena, Germany.ORCID https://orcid.org/0000-0002-0659-0238
Poh Soo LeeInstitute of Materials Science, Max Bergmann Center of Biomaterials, TUD Dresden University of Technology, Dresden, Germany.ORCID https://orcid.org/0000-0003-2285-3621

Funding

Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) 460388836DFG SFB 1270/12 - 299150580 ELAINEEuropean Regional Development Fund-Project Excellence in Regenerative Medicine CZ.02.01.01/00/22_008/0004562Internal Grant Agency of Jan Evangelista Purkyně University in Ústí nad Labem UJEP-IGA-2024-53-003-2Internal Grant Agency of Jan Evangelista Purkyně University in Ústí nad Labem UJEP-SGS-2023-53-005-3
6 · The paper itself

Abstract

The demand for off-the-shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end-products are often uniformly shaped and inferior to native bone tissue. In this report, three major technologies are implemented cohesively to address these shortfalls: (1) Spinner flasks for scaled-up stem cell expansion, (2) Manufacturing via 3D-printing and cast-molding processes, large modular collagen-based (COL) scaffolds +/- chondroitin sulfate A (CSA) of tailored dimensions, (3) Perfusion bioreactor with controlled oxygen tension (pO

Indexed as

3D‐printingbiomimetic bioreactorendochondral ossificationhuman mesenchymal stromal cellsmodular manufacturingoxygen tensionspinner flask

Identifiers

PMID42490685
PMCPMC13395396

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.