Evidence map›Paper›PMID 42490449›Full record

ArticleScience advances2026

Engineered probiotic

Jaehyun Lee, Kaiting Yang, Christina A Nowicki, Wei Liu, Kangdi Li, Emile Naccasha, Zhichen Sun, Yang-Xin Fu, Hua Liang, Ralph R Weichselbaum and 1 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jaehyun LeeDepartment of Microbiology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-0738-8071
Kaiting YangDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-9328-5655
Christina A NowickiDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-8110-9021
Wei LiuDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-0696-6407
Kangdi LiDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-3737-6573
Emile NaccashaDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.ORCID 0009-0005-5445-9313
Zhichen SunDepartment of Pathology, University of Texas Southwestern, Dallas, TX 75390, USA.ORCID 0000-0001-7837-8407
Yang-Xin FuDepartment of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China.ORCID 0000-0001-8441-6617
Hua LiangDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-5512-8595
Ralph R WeichselbaumDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-5643-8939
Mark MimeeDepartment of Microbiology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-3083-2671

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI KUNLE ODUNSI · 1985 to 2026
$122.1M
Genetically-engineered Bacteria Overcome Therapy ResistanceR01CA292860 · NCI · UNIVERSITY OF CHICAGO · PI Mark Mimee, RALPH R WEICHSELBAUM · 2024 to 2026
$2.9M
Immunoengineering Postdoctoral Training Program - Resubmission - 1T32AI153020 · NIAID · UNIVERSITY OF CHICAGO · PI ALEGRE, MARIA-LUISA, SWARTZ, MELODY ANN · 2021 to 2025
$2.1M
Elucidating the Roles of RNA m6A readers Y1 and Y2 in radiation-induced immunity and immunotherapyR01CA262508 · NCI · UNIVERSITY OF CHICAGO · PI WEICHSELBAUM, RALPH R · 2021 to 2025
$2.0M
NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA262508NCI NIH HHS R01 CA292860NIAID NIH HHS T32 AI153020
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) presents a substantial challenge due to its resistance to cancer treatments. This limited efficacy is, in part, attributed to the immunosuppressive tumor microenvironment (TME), which impairs effector T (T

Indexed as

BifidobacteriumCarcinoma, Pancreatic DuctalInterleukin-2Pancreatic NeoplasmsProbioticsAnimalsCell Line, TumorHumansImmunotherapyMiceT-Lymphocytes, RegulatoryTumor MicroenvironmentInterleukin-2

Identifiers

PMID42490449
PMCPMC13394381

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.