Evidence map›Paper›PMID 42490157›Full record

ArticleJCI insight2026

Characterizing enteric pathology in MPS IIIA mice suggests disease-specific vulnerability among lysosomal storage disorders.

Ewa A Ziółkowska, Letitia Williams, Elizabeth Eultgen, Grace R Kick, Xukai Ding, Alexander Sorensen, Steven Le, Balraj Doray, Patricia I Dickson, Robert O Heuckeroth and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ewa A ZiółkowskaDepartment of Animal Biotechnology and Genetics, Faculty of Animal Breeding and Biology, Bydgoszcz University of Science and Technology, Bydgoszcz, Poland.
Letitia WilliamsDepartment of Pediatrics, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.
Elizabeth EultgenDepartment of Pediatrics, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.
Grace R KickDepartment of Pediatrics, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.
Xukai DingDepartment of Pediatrics, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.
Alexander SorensenDepartment of Pediatrics, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.
Steven LeDepartment of Pediatrics, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.
Balraj DorayDepartment of Pediatrics, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.
Patricia I DicksonDepartment of Pediatrics, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.
Robert O HeuckerothChildren's Hospital of Philadelphia Research Institute and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jonathan D CooperDepartment of Pediatrics, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.

Funding

Defining non-genetic mechanisms that prevent death in a Hirschsprung disease mouse modelR01DK129691 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI HEUCKEROTH, ROBERT O · 2021 to 2024
$2.3M
Mechanistic human studies to prevent Hirschsprung-associated enterocolitisR01DK141691 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBERT O HEUCKEROTH · 2025 to 2026
$1.4M
Cellular Mechanisms of Enteric Nervous System Damage in CLN2 DiseaseR01NS140682 · NINDS · WASHINGTON UNIVERSITY · PI JONATHAN D COOPER · 2025 to 2026
$1.3M
Defining and treating enteric nervous system damage in Cln1 diseaseR21NS116574 · NINDS · WASHINGTON UNIVERSITY · PI COOPER, JONATHAN D · 2020 to 2020
$454k
NIDDK NIH HHS R01 DK129691NIDDK NIH HHS R01 DK141691NINDS NIH HHS R01 NS140682NINDS NIH HHS R21 NS116574
6 · The paper itself

Abstract

The gastrointestinal symptoms that impair quality of life in childhood neurodegenerative disorders, may be because bowel enteric neurons are also affected.

Indexed as

Enteric Nervous SystemLysosomal Storage DiseasesAnimalsDisease Models, AnimalHumansMiceNeuronsGastroenterologyGeneticsNeurodegenerationNeuroscience

Identifiers

PMID42490157
PMCPMC13564091

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.