ArticleMacromolecular bioscience2026
Alginate and Chitosan-Based Hydrogels: Effects on the Stability of Encapsulated Quercetin Under Multiple Stress Conditions.
Article in Macromolecular bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In this study, hydrogel systems were investigated as protective carriers for quercetin (Que), a sensitive phytopharmaceutical. Matrix-type calcium alginate microparticles and capsule-type calcium alginate-chitosan microparticles were subjected to processing relevant stresses, including storage at -20°C to 25°C for up to 30 days, repeated freeze-thaw cycling, thermal treatment up to 100°C, ultrasonic irradiation (40-200 W), microwave exposure (50-300 W), and UV irradiation (254 and 365 nm) for up to 60 min. The antioxidant activity of encapsulated Que was quantified using EPR spectroscopy based on DPPH radical-scavenging activity. The results demonstrate that polysaccharide-based carrier design plays key roles in determining payload functional stability under stress. Higher alginate concentrations significantly improved Que protection during frozen storage and high-intensity ultrasonic treatment, while chitosan coating provided additional interfacial shield. The alginate-chitosan system showed markedly enhanced resistance to thermal treatment, repeated freeze-thaw cycles, and microwave irradiation. Under moderate storage conditions (4°C and 25°C) and UV exposure, both alginate matrices and alginate-chitosan capsules exhibited comparable stabilization performance. Overall, this study provides quantitative structure-function insights into the stress-dependent protective behavior of polysaccharides and highlights the potential of polysaccharide-based hydrogels for improving the stability of antioxidant compounds during processing and storage in the food and pharmaceutical industry.
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