Evidence map›Paper›PMID 42489993›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2026

Multimodal microscopic and spectroscopic characterisation of heterogeneous iron oxyhydroxides in the human globus pallidus.

Martin Kopáni, Daniel Kosnáč, Pavol Gemeiner, Jana Hlinková, Pavol Janega, Ján Pánik, Štefan Polák

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Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Martin KopániInstitute of Medical Physics and Biophysics, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08, Bratislava, Slovakia.
Daniel KosnáčInstitute of Medical Physics and Biophysics, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08, Bratislava, Slovakia.
Pavol GemeinerDepartment of Graphic Arts Technology and Applied Photochemistry, Institute of Polymer and Synthetic Materials, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37, Bratislava, Slovakia.
Jana HlinkováInstitute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Pb 1109, Blindern, 0317, Oslo, Norway.
Pavol JanegaInstitute of Pathological Anatomy, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08, Bratislava, Slovakia.
Ján PánikInstitute of Medical Physics and Biophysics, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08, Bratislava, Slovakia. jan.panik@fmed.uniba.sk.ORCID https://orcid.org/0000-0001-9976-2256
Štefan PolákInstitute of Anatomy, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08, Bratislava, Slovakia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron is essential for neuronal metabolism, neurotransmitter synthesis, and enzymatic function; however, dysregulated accumulation contributes to oxidative stress and neurodegeneration. The basal ganglia, particularly the globus pallidus, represent a hotspot for iron deposition, yet the precise structural forms and their implications remain incompletely understood. Here, a multimodal approach was applied combining Raman microspectroscopy, light microscopy, transmission (TEM) and scanning electron microscopy coupled with energy-dispersive X-ray analysis (SEM-EDX) to characterise iron-rich deposits in post-mortem human globus pallidus. Tissue samples from six individuals without neurological disease were examined. Perls' staining revealed iron-positive, spherical inclusions 10-20 µm in diameter. Raman spectroscopy revealed bands at 268-278, 490, 526, and 603 cm

Indexed as

Ferric CompoundsGlobus PallidusHumansIronMicroscopy, Electron, ScanningSpectrum Analysis, RamanFerric Compoundsferric oxyhydroxideIronFerritinGlobus pallidusIron oxidesMagnetiteNeurodegenerationRaman spectroscopySEM–EDX

Identifiers

PMID42489993
PMCPMC13518459

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.