Evidence map›Paper›PMID 42489972›Full record

ArticleHernia : the journal of hernias and abdominal wall surgery2026

Enhancing the antimicrobial efficacy of polyester hernia meshes via layer-by-layer chitosan surface modification.

Dost Ali, Sheeza Rukhsar, Noor Sanbhal, Sadaf Tagar, Mazhar Ali Peerzada, Mazhar Ali Sanbhal, Hamza Ali Khan

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Article in Hernia : the journal of hernias and abdominal wall surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Dost AliDepartment of Textile, Mehran University of engineering and Technology, Jamshoro, Pakistan.
Sheeza RukhsarDepartment of Textile, Mehran University of engineering and Technology, Jamshoro, Pakistan.
Noor SanbhalDepartment of Textile, Mehran University of engineering and Technology, Jamshoro, Pakistan. noor.sanbhal@faculty.muet.edu.pk.
Sadaf TagarU.S.-Pakistan center for advanced studies in water, Mehran University of engineering and Technology, Jamshoro, Pakistan.
Mazhar Ali PeerzadaDepartment of Textile, Mehran University of engineering and Technology, Jamshoro, Pakistan.
Mazhar Ali SanbhalDepartment of Biomedical, Mehran University of Engineering, Jamshoro, Pakistan.
Hamza Ali KhanDepartment of Textile, Mehran University of engineering and Technology, Jamshoro, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolyester (PET)-based meshes are widely employed in hernia repair due to their superior mechanical properties and biocompatibility. However, their multifilament nature promotes bacterial adhesion and biofilm formation, increasing the risk of postoperative infections and recurrence.

methodIn this research, polyethylene terephthalate (PET) mesh was functionalized with chitosan using layer-by-layer coating in chitosan and citric acid layers. The PET meshes were soaked in chitosan and citric acid for 5 times and 10 times layer by layer to see the weight variance of both coated meshes. Moreover, chitosan coated PET meshes were loaded with levofloxacin for antibacterial properties.

resultsThe functionalized PET meshes were thoroughly characterized using scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, and Fourier transform infrared (FTIR) spectroscopy. SEM images confirmed the uniform deposition of the chitosan coating on the PET meshes. While EDX revealed the presence of deposited chitosan and levofloxacin HCL. The FTIR confirmed the successful cross-linking of chitosan with PET mesh. The antimicrobial efficacy of the coated meshes was assessed against Staphylococcus aureus and Escherichia coli using the agar diffusion method. The results demonstrated excellent antimicrobial activity, with minimum inhibition zones up to 10 mm. The antibacterial levofloxacin demonstrated the release performance of a soluble drug and inhibited bacterial growth. The PET coated with chitosan 10 times showed better results of the antibacterial inhibition zone in comparison to the 5-times layer-by-layer coated PET meshes.

Indexed as

Anti-Bacterial AgentsChitosanCoated Materials, BiocompatibleLevofloxacinSurgical MeshCitric AcidEscherichia coliHerniorrhaphyMicroscopy, Electron, ScanningPolyestersPolyethylene TerephthalatesSpectroscopy, Fourier Transform InfraredStaphylococcus aureusSurface PropertiesAnti-Bacterial AgentsChitosanCitric AcidCoated Materials, BiocompatibleLevofloxacinPolyestersPolyethylene TerephthalatesChitosanCitric acidHerniaLayer-by-layerLevofloxacinPolyester mesh

Identifiers

PMID42489972

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.