ReviewMolecular biology reports2026
Applications and prospects of the immunomodulatory and regenerative capabilities of gingival mesenchymal stem cells for chronic inflammation treatment.
Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
Abstract
Chronic inflammation is central to the pathogenesis of numerous severe diseases, and current therapeutic approaches are limited by suboptimal efficacy and significant adverse effects. The emergence of mesenchymal stem cells (MSCs) represents a groundbreaking advance, owing to their potent immunomodulatory and tissue-reparative capacities. Among diverse MSC sources, gingival mesenchymal stem cells (GMSCs) exhibit distinct advantages. Since their therapeutic potential was first demonstrated in 2009, GMSCs have shown considerable promise as a cellular therapeutic modality in a range of preclinical models. This review discusses the major immunomodulatory functions of GMSCs and synthesizes preclinical evidence supporting their therapeutic potential in two distinct but complementary domains: (1) chronic inflammatory conditions, including arthritis and periodontitis; and (2) broader regenerative medicine applications, such as nerve injury, bone injury, stroke, and tracheal defect repair. GMSCs attenuate inflammation and promote tissue repair through the secretion of anti-inflammatory factors. These mechanisms have been validated in various animal models, demonstrating promising therapeutic efficacy and favorable safety profiles. Additionally, this article explores innovative strategies-such as three-dimensional (3D) culture systems-to enhance GMSC therapeutic potential, as well as their applications in regenerative medicine. As technological advances continue to evolve, including the use of engineered extracellular vesicles (EVs) to fine-tune GMSC function, the future of precision immunotherapy and regenerative medicine utilizing GMSCs is highlighted. Collectively, fundamental research on GMSC-based therapies has elucidated the multiple immunomodulatory and regenerative pathways employed by these cells to achieve therapeutic effects, underscoring their substantial potential across both chronic inflammation and regenerative medicine applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.