ArticleJournal of gastrointestinal cancer2026
The Prognostic Impact of the Number of Colorectal Liver Metastases At the Time of Presentation Among Patients Undergoing Surgery.
Article in Journal of gastrointestinal cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prognostic impact of tumor number among surgically treated colorectal liver metastases (CLMs) remains incompletely understood, particularly in patients with extensive disease.
methodsWe retrospectively analyzed 303 patients who underwent initial hepatectomy for CLMs between 2008 and 2024. Prognostic factors for overall survival (OS) were evaluated using multivariable Cox regression analysis. Estimated mortality hazard at three and five years after surgery was modeled according to the number of liver lesions.
resultsTumor number (hazard ratio [HR], 1.02; 95% confidence interval [CI], 1.00-1.03; P = 0.025), positive primary nodal status (HR, 1.39; 95% CI 1.04-1.87; P = 0.029), and extrahepatic disease (HR, 1.60; 95% CI, 1.13-2.25; P = 0.007) were independently associated with OS. Mortality hazard gradually increased with increasing tumor number, particularly between 5-30 lesions, although the increase was modest. Among patients with ≥ 10 CLMs, median OS was 39.0 months.
conclusionsTumor number was associated with prognosis after hepatectomy, but increasing tumor burden did not result in a steep increase in mortality hazard. Tumor number alone should not preclude surgical consideration in selected patients.
Indexed as
Identifiers
42489965What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.