Evidence map›Paper›PMID 42489931›Full record

ArticleClinical oral investigations2026

Radiologic 3D tumor volume predicts cervical metastasis in oral squamous cell carcinoma.

A Schmitz, V Corneo, C Rendenbach, C Doll, F Elsholtz, K Kreutzer, F Mrosk, M Alfertshofer, M Heiland, S Koerdt

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Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

A SchmitzDepartment of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. alina-marie.schmitz@charite.de.
V CorneoDepartment of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
C RendenbachDepartment of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
C DollDepartment of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
F ElsholtzDepartment of Radiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
K KreutzerDepartment of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
F MroskDepartment of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
M AlfertshoferDepartment of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
M HeilandDepartment of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
S KoerdtDepartment of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo test whether pre-operative primary CT-based 3D tumor volume (TV) improves prediction of cervical spread in oral squamous cell carcinoma (OSCC) beyond conventional size metrics. MATERIALS AND

methodsWe retrospectively analyzed 132 consecutive primary OSCC patients (2014-2019). Contrast-enhanced CT datasets were semi-automatically segmented to obtain 3D TV (cm

resultsMedian CT-derived TV was 12.6 cm

conclusionsCT-based 3D volumetry is an independent pre-operative predictor of cervical LNM, flags tumors prone to skip spread, and offers greater clinical utility than linear measures. CLINICAL RELEVANCE: Integrating radiologic volumetry into staging could refine nodal management-particularly in clinically node-negative patients-by supporting risk-adapted selection between sentinel lymph-node biopsy and elective neck dissection; prospective validation is warranted.

Indexed as

Carcinoma, Squamous CellImaging, Three-DimensionalLymphatic MetastasisMouth NeoplasmsTomography, X-Ray ComputedTumor BurdenAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesBiomarkersMetastasisOSCCStagingTomographyVolumetry

Identifiers

PMID42489931
PMCPMC13395950

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.