ReviewReviews in endocrine & metabolic disorders2026
Mammary adipocyte plasticity and epithelial crosstalk: roles in development, remodeling, and disease.
Review in Reviews in endocrine & metabolic disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The mammary gland is a composite organ in which epithelial ducts and alveoli develop within a specialized adipose-rich stroma. Although mammary biology has traditionally been interpreted through an epithelium-centered framework, increasing evidence indicates that mammary adipocytes actively shape mammary development, reproductive remodeling, and disease susceptibility. Across puberty, pregnancy, lactation, and involution, mammary adipocytes undergo dynamic changes in cellular state, morphology, lipid handling, and stromal interactions, reflecting fate-related, phenotypic, and metabolic plasticity. Through adipokines, growth factors, metabolic substrates, extracellular matrix (ECM)-associated mechanical cues, and immune-inflammatory networks, mammary adipocytes influence epithelial behavior and tissue remodeling. Conversely, epithelial expansion, secretory differentiation, and post-weaning regression reshape the adipose-rich stromal niche. Dysregulation of this reciprocal adipose-epithelial ecosystem may contribute to aberrant tissue expansion, local estrogenic or inflammatory amplification, impaired adipose support, and tumor-permissive remodeling. Here, we review stage-specific epithelial-adipocyte crosstalk during mammary development, define mammary adipocyte plasticity across fate-related and functional dimensions, and discuss its relevance to benign breast disorders, tumor-associated remodeling, and disease susceptibility.
Indexed as
Identifiers
42489854What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.