ArticleAnnals of nuclear medicine2026
Impact of posture change on patient-specific absorbed dose estimation in nuclear medicine.
Article in Annals of nuclear medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeInternal dosimetry in nuclear medicine commonly assumes a fixed upright standing posture of subjects. The use of four recent therapeutic radionuclides with longer half-lives causes long exposure to patients during different daily activities and postures. This study aims to evaluate the effect of posture change on organ absorbed doses for seven radionuclides: diagnostic photon/positron-emitters (
methodWhole body Japanese adult male and female digital human phantoms (National Institute of Information and Communications Technology, Japan) in standing and sitting postures were used in this study. Based on the reference biodistribution of
resultsLarge differences in organ absorbed doses between the two postures were observed for diagnostic radionuclides, with ⁹⁹ᵐTc exhibiting more than 15% kidney dose differences. In contrast, therapeutic radionuclides showed less than 4% differences, as their energy deposition is dominated by self-dose.
conclusionIncorporating posture into internal dosimetry may improve the accuracy of absorbed dose estimation and support more personalized applications for diagnostic nuclear medicine.
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