Evidence map›Paper›PMID 42489772›Full record

ArticleMycopathologia2026

First Case of Candidemia Caused by Fluconazole-Resistant Candida orthopsilosis Harboring the ERG11 G458S Mutation in a Hematopoietic Stem Cell Transplant Recipient in Asia.

Tatsuro Hirao, Mizuki Haraguchi, Kyosuke Yamaguchi, Kazuhiro Horiba, Masahiro Abe, Ami Koizumi, Sayoko Oiki, Kosei Kageyama, Yuki Taya, Hideki Araoka and 2 more

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In one paragraph

Article in Mycopathologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tatsuro HiraoDepartment of Hematology, Toranomon Hospital Kajigaya, Kanagawa, Japan.
Mizuki HaraguchiDepartment of Infectious Diseases, Toranomon Hospital, 2-2-2, Toranomon, Minato-ku, Tokyo, 105-8470, Japan. mizuki.haraguchi87@gmail.com.ORCID https://orcid.org/0009-0009-6034-2786
Kyosuke YamaguchiDepartment of Hematology, Toranomon Hospital Kajigaya, Kanagawa, Japan.
Kazuhiro HoribaLaboratory of Microbial Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.
Masahiro AbeDepartment of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.
Ami KoizumiDepartment of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.
Sayoko OikiDepartment of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.
Kosei KageyamaDepartment of Hematology, Toranomon Hospital Kajigaya, Kanagawa, Japan.
Yuki TayaDepartment of Hematology, Toranomon Hospital Kajigaya, Kanagawa, Japan.
Hideki AraokaDepartment of Infectious Diseases, Toranomon Hospital, 2-2-2, Toranomon, Minato-ku, Tokyo, 105-8470, Japan.
Yoshitsugu MiyazakiLaboratory of Microbial Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.
Atsushi WakeDepartment of Hematology, Toranomon Hospital Kajigaya, Kanagawa, Japan.

Funding

AMED JP25fk0108679
6 · The paper itself

Abstract

Candidemia poses a life-threatening complication for immunocompromised patients, including those undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Non-albicans Candida species are increasingly recognized as causative pathogens in this population, with azole resistance having emerged as a global concern. Candida orthopsilosis, a member of the Candida parapsilosis species complex, is generally considered susceptible to azole antifungal agents. Although sporadic reports of azole-resistant isolates have surfaced worldwide, no such cases have been documented in Japan. Furthermore, genetic evaluations of azole-resistant C. orthopsilosis have primarily been conducted in Europe. We present the first case of fluconazole-resistant C. orthopsilosis bloodstream infection in a 73-year-old man following allo-HSCT for acute myeloid leukemia in Japan. Whole-genome sequencing identified an ERG11 G458S substitution, a known mechanism of fluconazole resistance in C. orthopsilosis, representing the first identification of this mutation outside Europe. Our findings highlight the importance of continued surveillance of antifungal resistance in C. orthopsilosis.

Indexed as

Antifungal AgentsCandida parapsilosisCandidemiaCytochrome P-450 Enzyme SystemDrug Resistance, FungalFluconazoleHematopoietic Stem Cell TransplantationMutation, MissenseAgedHumansImmunocompromised HostJapanLeukemia, Myeloid, AcuteMaleMicrobial Sensitivity TestsTransplant RecipientsAntifungal AgentsCytochrome P-450 Enzyme SystemFluconazoleAntifungal resistanceCandida orthopsilosisCandidemiaERG11Fluconazole

Identifiers

PMID42489772

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.