ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Ocular biometry in isolated versus disease-associated high myopia in children and adolescents: A retrospective observational study.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundPediatric high myopia (HM) is increasingly recognized as a heterogeneous condition, arising either idiopathically or in association with underlying ocular or genetic disorders. Disease-associated HM may show distinct biometric characteristics, yet comparative data in children remain limited. This study characterized ocular biometry in isolated HM (IHM) and disease-associated HM related to familial exudative vitreoretinopathy (FEVR), myelinated retinal nerve fibers (MRNF), Stickler syndrome (SS), and epiretinal membrane (ERM).
methodsWe retrospectively analyzed patients aged ≤ 18 years with HM, defined as spherical equivalent (SE) ≤ - 5.0 diopters (D) or axial length (AL) ≥ 26.0 mm, who underwent comprehensive examinations. Biometric parameters were obtained using the IOLMaster 700. Linear mixed-effects models accounted for inter-eye correlation, and estimated marginal means with Benjamini-Hochberg-adjusted pairwise comparisons were used for statistical inference.
resultsA total of 131 patients (186 eyes) were included. Of 186 affected eyes, 37.1% had extreme HM. Biometric differences were observed between IHM and disease groups: MRNF eyes had larger white-to-white diameters and lower astigmatism. FEVR eyes had shorter axial length, shallower anterior chambers, and steeper corneas. SS eyes showed thinner lenses, flatter corneas, and higher VCD: AL ratios. ERM eyes had shorter AL and deeper anterior chambers.
conclusionsDistinct etiologies of pediatric HM demonstrate characteristic biometric signatures. While MRNF resembles IHM, FEVR, ERM, and SS show unique anterior and posterior segment alterations that may improve diagnostic accuracy and individualized management.
Indexed as
Identifiers
42489687What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.