ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2026
Molecular strategies for flux control in an electron bifurcation protein.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Electron-bifurcating flavoproteins split electron pairs and deposit them in spatially separated electron-acceptor pools. Just how electron-transfer networks regulate steady-state electron-bifurcation (EB) fluxes and efficiencies remains unclear. We model the steady-state kinetics of electron-bifurcation in NADH-dependent ferredoxin-NADP[Formula: see text] oxidoreductase I (Nfn1), based on the protein's structure and electrochemistry. We use a many-particle master-equation to simulate the steady-state kinetics. The analysis identifies control points that are defined by electronic couplings between cofactors, and we explore how the interactions between cofactors influence EB function. We find that couplings on the low-potential branch dictate EB efficiency and the onset of short-circuiting, while the couplings on the high-potential branch determine the magnitude of the steady-state bifurcation flux in Nfn1. Analysis of interactions using the tunneling pathway model indicates that pathway connectivity between the bifurcating donor and its high-potential acceptor is weak for its distance; this decoupling may serve to further suppress short-circuiting and favor productive electron flow.
Indexed as
Identifiers
42489679What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.