Evidence map›Paper›PMID 42489478›Full record

ArticleMicrobiology spectrum2026

Time-resolved mapping in calves reveals bovine herpesvirus 1 shift from mucosal replication to trigeminal ganglion neuroinvasion with promyelocytic leukemia protein-centered host-virus antagonism.

Yong Wang, Huan Jin, Fanyu Wang, Jing Cheng, Mengyao Cao, Linyi Zhou, Wenxiao Liu, Yongqing Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yong Wang *Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.ORCID 0009-0001-5927-372X
Huan Jin *Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.
Fanyu Wang *School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Jing Cheng *Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.
Mengyao CaoInstitute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.
Linyi ZhouInstitute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.
Wenxiao LiuInstitute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.
Yongqing LiInstitute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.ORCID 0000-0002-0072-5154

Funding

Beijing Innovation Team of Technology Systems in the Dairy Industry BAIC06-2025National Key Research and Development Program of China 2024YFD1301003National Natural Science Foundation of China 32172818Natural Science Foundation of Beijing Municipality 6232012Special Program on Science and Technology Innovation Capacity Building of BAAFS KJCX20230424
6 · The paper itself

Abstract

Although bovine herpesvirus 1 (BoHV-1) causes massive losses of cattle, the transition from mucosal replication to neuroinvasion remains poorly understood. Using a controlled calf model, we integrated quantitative virology and transcriptomics to map its pathogenesis and define the role of promyelocytic leukemia protein (PML). Calves inoculated intranasally and ocularly (1.4 × 10

Indexed as

Cattle DiseasesHerpesviridae InfectionsHerpesvirus 1, BovinePromyelocytic Leukemia ProteinTrigeminal GanglionVirus ReplicationAnimalsCattleHost-Pathogen InteractionsPromyelocytic Leukemia Proteinbovine herpesvirus 1 (BoHV-1)interferon-α (IFN-α)promyelocytic leukemia protein (PML)trigeminal ganglion neuroinvasionviral antagonism

Identifiers

PMID42489478
PMCPMC13532201

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.