Evidence map›Paper›PMID 42489277›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A High-Loading Zn Single-Atom Nanozyme Targets the Zn/HIF-1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment.

Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun and 3 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhenxin WangDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Yuhang TangDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Ronghao YueDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Jingtao XuDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Yong TaoDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Jie ChenDepartment of Core Laboratory, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Shipeng LiDepartment of Emergency Medicine Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Guosheng ZhaoDepartment of Orthopaedic Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Jinfang XueDepartment of Emergency Medicine Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Mingwei SunDepartment of Emergency Medicine Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Fenglei GaoKey Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Jiangsu, China.ORCID https://orcid.org/0009-0009-8197-6577
Yunsheng OuDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0001-8578-3523
Yang WangDepartment of Emergency Medicine Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0001-5407-138X

Funding

Chongqing Medical University First Clinical College Graduate Supervisor Team Construction Project CYYY-XKDFJH-DSTD-202503Doctoral Research Innovation Project of the First Clinical College of Chongqing Medical University CYYY-BSCX202518Health Commission of Sichuan Province Medical Science and Technology Program 24QNMP097National Natural Science Foundation of China 82172682National Natural Science Foundation of China 82303712National Natural Science Foundation of China 82373221
6 · The paper itself

Abstract

Highly metastatic osteosarcoma exhibits marked resistance to conventional therapies, driven by glucose-metabolic reprogramming together with disturbed zinc homeostasis. This study reveals that the TRPML1/HIF-1α/GLUT1 axis as a mechanistic link between lysosomal zinc homeostasis and glucose-metabolic regulation, thereby dictating tumor cell fate. On this basis, we developed a TRPML1-activation-based single-atom nanozyme platform with dual enzymatic activities (ZMG@CS) to synchronously collapse ionic and redox homeostasis within lysosomes. Following the lysosomal accumulation of ZMG@CS, high-density Zn single-atom sites enabled peroxidase-like catalysis, whereas the delivered glucose oxidase (GOx) acidified the local environment through glucose consumption, collectively amplifying oxidative stress. TRPML1 activation promoted Zn

Indexed as

disulfidptosisimmunotherapypyroptosissingle‐atom nanozymeTRPML1

Identifiers

PMID42489277
PMCPMC13393267

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.