Evidence map›Paper›PMID 42489268›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Engineering-Modulated Molybdenum Enzymes Strategy for Tumor-Specific Metabolic-Immunotherapy.

Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xiaoxiao PanInstitute of Functional Nano & Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, Suzhou, China.
Zifan PeiInstitute of Functional Nano & Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, Suzhou, China.ORCID https://orcid.org/0009-0001-6166-9678
Jie WuInstitute of Functional Nano & Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, Suzhou, China.ORCID https://orcid.org/0009-0007-9403-9799
Nan JiangDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Qian LiDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yuqi YangInstitute of Functional Nano & Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, Suzhou, China.
Jie CaoInstitute of Functional Nano & Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, Suzhou, China.
Yechen HuangInstitute of Functional Nano & Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, Suzhou, China.
Shumin SunInstitute of Functional Nano & Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, Suzhou, China.
Qialu DuInstitute of Functional Nano & Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, Suzhou, China.
Zhicheng LiuInstitute of Functional Nano & Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, Suzhou, China.
Lin ZhangDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Fei GongInstitute of Functional Nano & Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0002-7603-8553
Jinhua ZhouDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Liang ChengInstitute of Functional Nano & Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0001-5324-9094

Funding

111 ProjectCollaborative Innovation Center of Suzhou Nano Science and TechnologyJoint International Research Laboratory of Carbon-Based Functional Materials and Devices, Science and Technology Development 0016/2024/RIA1Joint International Research Laboratory of Carbon-Based Functional Materials and Devices, Science and Technology Development 0064/2024/AMJJoint International Research Laboratory of Carbon-Based Functional Materials and Devices, Science and Technology Development 0118/2023/RIA2National Natural Science Foundation of China 52203362National Natural Science Foundation of China 52472288National Natural Science Foundation of China 52572306National Natural Science Foundation of China U25A20246Natural Science Foundation of Jiangsu Province BK20250005Natural Science Foundation of Jiangsu Province BK20255001The Suzhou Municipal Health Commission Project LCZX202303The Suzhou Municipal Key Discipline of Obstetrics and Gynecology SZXK202504
6 · The paper itself

Abstract

Molybdenum enzymes and one of their catalytic products, uric acid (UA), play important roles in T-cell activation; thereby, enhancing molybdenum enzyme activity and increasing UA levels within tumors can further activate T-cell and enhance anti-tumor immunotherapy. To achieve this goal, biodegradable molybdenum sulfide nanoparticles (MoS

Indexed as

cGAS‐STINGmetabolic‐immune therapymolybdenum enzymesT‐cell activationuric acid

Identifiers

PMID42489268
PMCPMC13393259

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.