Evidence map›Paper›PMID 42489248›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke-Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling.

Kyung-Joo Seong, Sehoon Park, Sun-Woong Bae, Daseul Kim, Jin Ho Lee, Won-Seok Choi, Zee-Yong Park, Ji-Yeon Jung, Won-Jae Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kyung-Joo SeongDental Science Research Institute, Stem Cell Secretome Research Center, Hard-tissue Biointerface Research Center, Department of Oral Physiology, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea.
Sehoon ParkGIST InnoCORE AI-Nano Convergence Institute for Early Detection of Neurodegenerative Diseases, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
Sun-Woong BaeDental Science Research Institute, Stem Cell Secretome Research Center, Hard-tissue Biointerface Research Center, Department of Oral Physiology, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea.
Daseul KimGIST InnoCORE AI-Nano Convergence Institute for Early Detection of Neurodegenerative Diseases, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
Jin Ho LeeSchool of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea.
Won-Seok ChoiSchool of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea.
Zee-Yong ParkGIST InnoCORE AI-Nano Convergence Institute for Early Detection of Neurodegenerative Diseases, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
Ji-Yeon JungDental Science Research Institute, Stem Cell Secretome Research Center, Hard-tissue Biointerface Research Center, Department of Oral Physiology, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea.
Won-Jae KimDental Science Research Institute, Stem Cell Secretome Research Center, Hard-tissue Biointerface Research Center, Department of Oral Physiology, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea.ORCID https://orcid.org/0000-0001-6549-744X

Funding

Chonnam National University Hospital Research Institute of Clinical Medicine BCRI26028InnoCORE program of the Ministry of Science and ICT GIST InnoCORE KH0860Ministry of Health and Welfare and the Ministry of Science and ICT, Republic of Korea HU23C0199National Research Foundation of Korea NRF-2021R1C1C2005005National Research Foundation of Korea NRF-2022R1A2C1008368National Research Foundation of Korea NRF-RS-2019-NR040056National Research Foundation of Korea NRF-RS-2025-19612993
6 · The paper itself

Abstract

Ischemic stroke induces oxidative stress, neuroinflammation, neuronal death, and synaptic dysfunction, leading to persistent motor and cognitive deficits. The human dental pulp stem cell (hDPSC) secretome is a promising cell-free therapeutic candidate containing neurotrophic, antioxidant, and immunomodulatory factors. Here, we investigated its therapeutic effects in a photothrombotic mouse model of ischemic stroke and CoCl

Indexed as

dental pulp stem cell secretomeischemic strokemicroglial polarizationneuroinflammationredox signalingsynaptic remodeling

Identifiers

PMID42489248
PMCPMC13393272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.