Evidence map›Paper›PMID 42489242›Full record

ArticleClinical and experimental dental research2026

Analysis of the Clinical Application Value of Immune Function Markers and Cytokines in the Recurrent Aphthous Ulcer.

Yiwen Chen, Ting Meng, Lahong Zhang, Qiang Ke

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In one paragraph

Article in Clinical and experimental dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yiwen ChenClinical Laboratory Department, Hangzhou Normal University Affiliated Hospital, Hangzhou, Zhejiang, China.ORCID 0000-0003-4249-9703
Ting MengMedical Laboratory Techology School, Wengzhou Medical University Renji College, Wenzhou, Zhejiang, China.
Lahong ZhangClinical Laboratory Department, Hangzhou Normal University Affiliated Hospital, Hangzhou, Zhejiang, China.
Qiang KeClinical Laboratory Department, Hangzhou Normal University Affiliated Hospital, Hangzhou, Zhejiang, China.

Funding

Hangzhou Biomedicine and Health Industry Development Fund 2022WJC254Hangzhou Science and Technology Development Plans 20201203B306Zhejiang Medical and Health Technology Program 2019KY133Zhejiang Medical and Health Technology Program 2023KY957
6 · The paper itself

Abstract

backgroundThis study aimed to analyze the alterations in cellular and humoral immune functions, alongside cytokine profiles, in patients with recurrent aphthous ulcer (RAU) compared to those with other oral mucosal diseases and healthy controls (HC), and to investigate their clinical significance.

methodsAnticoagulated whole blood and serum samples were collected from 101 cases of the RAU group, the "Others" group, and the HC group. The percentages of lymphocyte subsets, including NKT, NK, CD4

resultsNon-parametric tests revealed that the percentage of NKT cells in the RAU group was significantly higher than those in both the "Others" and HC groups; furthermore, the "Others" group showed significantly higher levels than the HC group. The content of IgE in the RAU group was significantly elevated compared to the "Others" and HC groups. The levels of IL-6, IL-8, and TNF-α in the RAU group were significantly higher than those in the HC group. ROC analysis revealed that NKT cells, IgE, IL-6, and IL-8 showed AUC values greater than 0.7 in the diagnosis of RAU.

conclusionThis study demonstrates that the combined detection of NKT cells, IgE, and cytokines (IL-6, IL-8, and TNF-α) may potentially hold significant clinical application value in the assessment of RAU and other oral mucosal diseases.

Indexed as

CytokinesStomatitis, AphthousAdultBiomarkersCase-Control StudiesFemaleHumansImmunity, CellularImmunoglobulin EInterleukin-8Lymphocyte SubsetsMaleMiddle AgedNatural Killer T-CellsRecurrenceTumor Necrosis Factor-alphaBiomarkersCytokinesImmunoglobulin EInterleukin-8Tumor Necrosis Factor-alphacytokineimmune functionrecurrent aphthous ulcer

Identifiers

PMID42489242
PMCPMC13393289

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.