Evidence map›Paper›PMID 42489108›Full record

ArticleThe Cochrane database of systematic reviews2026

Nucleic acid-based therapies for people with cystic fibrosis.

Charlotte Addy, Nikolas Johl, Andrew P Prayle, Nikki Jahnke, Sherie Smith, Cochrane Cystic Fibrosis

Abstract read
In one paragraph

Article in The Cochrane database of systematic reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Charlotte AddyAll Wales Adult Cystic Fibrosis Centre, Cardiff and Vale University Health Board, Cardiff, UK.ORCID https://orcid.org/0000-0002-4207-4409
Nikolas JohlAll Wales Adult Cystic Fibrosis Centre, Cardiff and Vale University Health Board, Cardiff, UK.ORCID https://orcid.org/0009-0008-9468-0268
Andrew P PrayleSchool of Medicine and NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK.ORCID https://orcid.org/0000-0002-1514-2840
Nikki JahnkeAcademic Unit of Lifespan and Population Health, Medicine & Health Sciences, University of Nottingham, Nottingham, UK.ORCID https://orcid.org/0000-0001-7836-0151
Sherie SmithAcademic Unit of Lifespan and Population Health, Medicine & Health Sciences, University of Nottingham, Nottingham, UK.ORCID https://orcid.org/0000-0002-4143-5364
Cochrane Cystic Fibrosis

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of nucleic acid-based therapies in people with CF of any age and any genotype.

Indexed as

Cystic FibrosisGenetic TherapyHumans

Identifiers

PMID42489108
PMCPMC13393079

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.