Evidence map›Paper›PMID 42488983›Full record

ReviewJournal of cellular physiology2026

Arginine Methylation in Alternative Splicing: Implications for Cancer Therapy.

Youyue Li, Shuyu Chen, Wenbo Ding, Bei Pan, Yujuan Yin, Xiaoqi Xin, Die Xia, Xueyang Wei, Siqi Bao, Mu Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cellular physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Youyue LiGeneral Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Shuyu ChenGeneral Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Wenbo DingGeneral Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Bei PanDepartment of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Yujuan YinGeneral Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Xiaoqi XinGeneral Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Die XiaGeneral Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Xueyang WeiGeneral Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Siqi BaoGeneral Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Mu XuSchool of Basic Medicine and Clinical Pharmacy, Nanjing First Hospital, China Pharmaceutical University, Nanjing, China.ORCID 0009-0000-6179-4412

Funding

Nanjing Medical and Health Scientific Research Project YKK22104National Natural Science Foundation of China 82203489
6 · The paper itself

Abstract

Arginine methylation is a common post-translational modification that exists in three distinct forms-monomethylation, asymmetric dimethylation, and symmetric dimethylation-through which it regulates precursor RNA splicing and maintains cellular homeostasis. Dysregulation of the writing, reading, or erasure of arginine methylation promotes cancer development. Recent studies have identified PRMTs as key regulators of alternative splicing, and aberrant PRMT-driven splicing directly impacts multiple biological processes, including tumor proliferation, apoptosis resistance, metastasis, and immune evasion. This review focuses on the molecular mechanisms by which PRMTs regulate alternative splicing, their connections to oncogenic processes, and the therapeutic implications and challenges of targeting the PRMT-splicing axis in cancer.

Indexed as

Alternative SplicingArginineNeoplasmsProtein-Arginine N-MethyltransferasesAnimalsGene Expression Regulation, NeoplasticHumansMethylationProtein Processing, Post-TranslationalArginineProtein-Arginine N-Methyltransferasesalternative splicingarginine methylationcancer therapymethylargininesPRMTs

Identifiers

PMID42488983
PMCPMC13392843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.