Evidence map›Paper›PMID 42488949›Full record

ArticleCirculation. Cardiovascular imaging2026

Pathology-Based Validation of Quantitative SPECT/CT in Patients With Suspected Transthyretin Amyloid Cardiomyopathy.

Gregorio Tersalvi, Melanie C Bois, Christopher G Scott, Patricia Carey, Armin Garmany, Daniel R Davies, Andrew C Hoffman, Jun Zhang, Carrie B Hruska, Hayan Jouni and 14 more

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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5 · Who and what money

Authors and funding

24 authors.

Gregorio TersalviDepartment of Cardiovascular Medicine (G.T., M.C.B., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., I.C.C., M.G., J.J.M., M.M.R., P. Chareonthaitawee, O.F.A.E.), Mayo Clinic, Rochester, MN.ORCID 0000-0003-1845-1777
Melanie C BoisDepartment of Cardiovascular Medicine (G.T., M.C.B., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., I.C.C., M.G., J.J.M., M.M.R., P. Chareonthaitawee, O.F.A.E.), Mayo Clinic, Rochester, MN.
Christopher G ScottDepartment of Quantitative Health Sciences (C.G.S.), Mayo Clinic, Rochester, MN.ORCID 0000-0003-1340-0647
Patricia CareyDepartment of Internal Medicine (P. Carey), Mayo Clinic, Rochester, MN.ORCID 0000-0002-9204-913X
Armin GarmanyMayo Clinic Alix School of Medicine, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN (A.G.).ORCID 0000-0002-5518-8544
Daniel R DaviesAGH McGinnis Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA (D.R.D.).ORCID 0000-0001-7774-0451
Andrew C HoffmanDepartment of Radiology (A.C. Hoffman, J.Z., C.B.H., J.P.B., N.S.A., A.C. Homb, G.B.J.), Mayo Clinic, Rochester, MN.
Jun ZhangDepartment of Radiology (A.C. Hoffman, J.Z., C.B.H., J.P.B., N.S.A., A.C. Homb, G.B.J.), Mayo Clinic, Rochester, MN.ORCID 0000-0002-6515-601X
Carrie B HruskaDepartment of Radiology (A.C. Hoffman, J.Z., C.B.H., J.P.B., N.S.A., A.C. Homb, G.B.J.), Mayo Clinic, Rochester, MN.ORCID 0000-0002-6195-5201
Hayan JouniDepartment of Cardiovascular Medicine (G.T., M.C.B., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., I.C.C., M.G., J.J.M., M.M.R., P. Chareonthaitawee, O.F.A.E.), Mayo Clinic, Rochester, MN.
Martin G Rodriguez-PorcelDepartment of Cardiovascular Medicine (G.T., M.C.B., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., I.C.C., M.G., J.J.M., M.M.R., P. Chareonthaitawee, O.F.A.E.), Mayo Clinic, Rochester, MN.
J Wells AskewDepartment of Cardiovascular Medicine (G.T., M.C.B., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., I.C.C., M.G., J.J.M., M.M.R., P. Chareonthaitawee, O.F.A.E.), Mayo Clinic, Rochester, MN.ORCID 0009-0000-6759-4032
John P BoisDepartment of Cardiovascular Medicine (G.T., M.C.B., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., I.C.C., M.G., J.J.M., M.M.R., P. Chareonthaitawee, O.F.A.E.), Mayo Clinic, Rochester, MN.
Kathleen A YoungDepartment of Cardiovascular Medicine (G.T., M.C.B., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., I.C.C., M.G., J.J.M., M.M.R., P. Chareonthaitawee, O.F.A.E.), Mayo Clinic, Rochester, MN.ORCID 0000-0002-7071-192X
Nandan S AnavekarDepartment of Cardiovascular Medicine (G.T., M.C.B., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., I.C.C., M.G., J.J.M., M.M.R., P. Chareonthaitawee, O.F.A.E.), Mayo Clinic, Rochester, MN.
Ian C ChangDepartment of Cardiovascular Medicine (G.T., M.C.B., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., I.C.C., M.G., J.J.M., M.M.R., P. Chareonthaitawee, O.F.A.E.), Mayo Clinic, Rochester, MN.
Martha GroganDepartment of Cardiovascular Medicine (G.T., M.C.B., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., I.C.C., M.G., J.J.M., M.M.R., P. Chareonthaitawee, O.F.A.E.), Mayo Clinic, Rochester, MN.ORCID 0000-0002-2541-4440
Angela DispenzieriDivision of Hematology, Department of Medicine (A.D.), Mayo Clinic, Rochester, MN.ORCID 0000-0001-8780-9512
Joseph J MaleszewskiDepartment of Cardiovascular Medicine (G.T., M.C.B., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., I.C.C., M.G., J.J.M., M.M.R., P. Chareonthaitawee, O.F.A.E.), Mayo Clinic, Rochester, MN.ORCID 0000-0003-3239-6460
Andrew C HombDepartment of Radiology (A.C. Hoffman, J.Z., C.B.H., J.P.B., N.S.A., A.C. Homb, G.B.J.), Mayo Clinic, Rochester, MN.
Margaret M RedfieldDepartment of Cardiovascular Medicine (G.T., M.C.B., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., I.C.C., M.G., J.J.M., M.M.R., P. Chareonthaitawee, O.F.A.E.), Mayo Clinic, Rochester, MN.ORCID 0000-0002-0946-7518
Panithaya ChareonthaitaweeDepartment of Cardiovascular Medicine (G.T., M.C.B., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., I.C.C., M.G., J.J.M., M.M.R., P. Chareonthaitawee, O.F.A.E.), Mayo Clinic, Rochester, MN.ORCID 0000-0002-3811-8712
Geoffrey B JohnsonDepartment of Radiology (A.C. Hoffman, J.Z., C.B.H., J.P.B., N.S.A., A.C. Homb, G.B.J.), Mayo Clinic, Rochester, MN.ORCID 0000-0002-9781-4072
Omar F AbouEzzeddineDepartment of Cardiovascular Medicine (G.T., M.C.B., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., I.C.C., M.G., J.J.M., M.M.R., P. Chareonthaitawee, O.F.A.E.), Mayo Clinic, Rochester, MN.ORCID 0000-0003-3256-3660

Funding

MSTP at Mayo Clinic RochesterT32GM145408 · NIGMS · MAYO CLINIC ROCHESTER · PI SCOTT H KAUFMANN, LISA A SCHIMMENTI · 2023 to 2026
$4.7M
NIGMS NIH HHS T32 GM145408
6 · The paper itself

Abstract

backgroundTechnetium-based cardiac amyloid radionuclide imaging enables noninvasive diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM), but conventional planar and visual semiquantitative approaches have important limitations. We developed the quantitative 3-dimensional Mayo 3D Score, defined as the ratio of mean left ventricular myocardial radiotracer uptake to right atrial blood-pool uptake using computed tomography (CT)-fused single-photon emission CT (SPECT) volumes of interest, and sought to validate its diagnostic performance against myocardial pathology.

methodsConsecutive patients who underwent

resultsAmong 230 patients (median age, 72 years; 78% male), 107 (47%) had ATTR-CM, of whom 9 had hereditary ATTR-CM. The Mayo 3D Score showed excellent discrimination against pathology (area under the receiver operating characteristic curve, 0.92 [0.88-0.96]), exceeding planar Perugini (0.87 [0.83-0.92];

conclusionsIn patients with suspected ATTR-CM undergoing

Indexed as

Amyloid Neuropathies, FamilialCardiomyopathiesMyocardiumSingle Photon Emission Computed Tomography Computed TomographyAgedAged, 80 and overFemaleHumansMaleMiddle AgedPredictive Value of TestsRadiopharmaceuticalsReproducibility of ResultsRetrospective StudiesTechnetium Tc 99m PyrophosphateRadiopharmaceuticalsTechnetium Tc 99m Pyrophosphateamyloidosisbiomarkerscardiomyopathiestechnetiumuncertainty

Identifiers

PMID42488949
PMCPMC13502208

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