ArticleJournal of surgical case reports2026
A case of chronic cholangitis caused by calculi with foreign matter mimicking perihilar cholangiocarcinoma.
Article in Journal of surgical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Perihilar cholangiocarcinoma (pCCA), originating from the second-order bile ducts and extending to the cystic duct insertion, is the most common cholangiocarcinoma subtype and carries a dismal prognosis. It is typically characterized by obstructive jaundice and elevated serum carbohydrate antigen 19-9 (CA19-9); however, these features significantly overlap with those of benign biliary diseases. While endoscopic retrograde cholangiopancreatography-guided tissue sampling is crucial for diagnosis, its sensitivity remains suboptimal. Consequently, up to 15% of preoperatively suspected pCCA cases are confirmed as benign strictures postoperatively. Given the close association between choledocholithiasis and pCCA, distinguishing malignancy from stone-induced inflammatory disease remains a significant diagnostic challenge. Herein, we report a rare case of chronic cholangitis mimicking pCCA, ultimately attributed to calculi containing a retained foreign body.
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