ArticlePlastic and reconstructive surgery. Global open2026
Predictors of Recurrence in Hand Giant Cell Tumor of Tendon Sheath: A Systematic Review.
Article in Plastic and reconstructive surgery. Global open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Background: Giant cell tumor of the tendon sheath is the second most common soft tissue tumor of the hand. However, reported recurrence rates vary widely (3%-45%), complicating the balance between radical excision and functional preservation. We performed a systematic review to (1) determine the pooled postoperative recurrence rate and (2) identify risk factors associated with recurrence. Methods: We conducted a preferred reporting items for systematic reviews and meta-analyses (PRISMA)-guided review of MEDLINE, Embase, and Cochrane CENTRAL in April 2024. We synthesized data from 12 cohort studies (10 retrospective, 2 prospective; n = 876) to calculate the pooled recurrence rate and analyzed 38 case reports to explore predictors of recurrence using logistic regression. Methodological quality was assessed using the Newcastle-Ottawa Scale. Results: Pooled recurrence across 11 studies was 13% (95% confidence interval 11%-15%; 107/838 patients). Mean follow-up was 4.2 years, with recurrence typically identified approximately 40 months postoperatively. Fifth-digit involvement was strongly associated with recurrence (odds ratio 18.3; 95% confidence interval 1.0-178.2; Conclusions: Recurrence is frequent (~13%), and significantly more likely in the little finger, plausibly due to anatomical constraints that hinder complete excision. Surgeons should ensure meticulous margin clearance when treating fifth-digit lesions, followed by prolonged surveillance.
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