Evidence map›Paper›PMID 42488915›Full record

ArticleFrontiers in global women's health2026

PRESHA - Preventing severe hypertensive adverse events in pregnancy and childbirth: a study protocol for establishing a prospective cohort study and biobank in urban Tanzania.

Andrea Solnes Miltenburg, Richard Kiritta, Benson R Kidenya, Hannah Brown Amoakoh, Peter C J I Schielen, Felix Manyogote, Hanne Ochieng Lichtwarck, Albert Kihunrwa, Johanne Sundby, Ingvil Sørbye and 5 more

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In one paragraph

Article in Frontiers in global women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Andrea Solnes Miltenburg *Department of Community Medicine and Global Health, Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.
Richard Kiritta *Department of Obstetrics and Gynaecology, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Benson R KidenyaDepartment of Biochemistry and Molecular Biology, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Hannah Brown AmoakohNoguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Peter C J I SchielenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Felix ManyogoteDepartment of Obstetrics and Gynaecology, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Hanne Ochieng LichtwarckDepartment of Community Medicine and Global Health, Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.
Albert KihunrwaDepartment of Obstetrics and Gynaecology, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Johanne SundbyDepartment of Community Medicine and Global Health, Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.
Ingvil SørbyeFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ewoud SchuitJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Karel G M MoonsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Anne Cathrine StaffFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Elia MmbagaDepartment of Community Medicine and Global Health, Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.
Joyce L BrowneJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Hypertensive disorders of pregnancy are a leading cause of maternal and perinatal mortality in low- and middle income settings. Yet, to date few large-scale prospective clinical studies in this field are conducted in sub-Saharan Africa. This paper describes the study protocol of a prospective cohort study, the PRESHA (PREventing Severe Hypertensive Adverse Events) cohort in Mwanza, Tanzania. The PRESHA study aims to reduce maternal and neonatal mortality and morbidity related to preeclampsia (PE) through improved prediction, prevention and clinical management. More specifically, within the cohort we aim to improve antenatal risk prediction of PE by externally validating existing biomarker-based (PlGF and sFlt-1) risk prediction models. Methods and design: Recruitment for a prospective cohort study of 3,000 women started August 2025 and is ongoing. Eligible for enrolment are women between 10 Discussion: This prospective cohort study offers comprehensive and contextually relevant data contributing to improving antenatal risk prediction for PE in a low-resource setting. The establishment of a new pregnancy database in Tanzania allows for identification of the impact of social or environmental determinants of health, risks of pregnancy complications and effect of health seeking behaviour. Future discovery studies of other predictors and diagnostics tools for placenta disorders will be possible with the established biobank.

Indexed as

biobankbiomarkershypertensive disorders of pregnancymaternal healthpreeclampsia

Identifiers

PMID42488915
PMCPMC13388734

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.