Evidence map›Paper›PMID 42488911›Full record

ArticleCurrent opinion in biomedical engineering2026

Stromal cell-mediated tuning of the extracellular matrix for immune tissue engineering.

Jennifer H Hammel

Abstract read
In one paragraph

Article in Current opinion in biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jennifer H HammelDepartment of Biomedical Engineering, Duke University, 534 Research Drive, Durham, NC 27710.

Funding

Duke KURe ProgramK12DK100024 · NIDDK · DUKE UNIVERSITY · PI Cindy Amundsen · 2013 to 2026
$8.4M
NIDDK NIH HHS K12 DK100024
6 · The paper itself

Abstract

Advancing in vitro models of immune tissues is a major focus toward answering lingering questions about immunity and developing physiologically relevant drug testing platforms. The composition and structure of the extracellular matrix is an essential consideration in these models as these physical cues can modulate immune cell behavior and ability to mount an immune response. In immune tissues, stromal cells deposit and maintain the extracellular matrix, yet they are often overlooked in existing engineered models. Within, three major strategies for tuning the extracellular matrix in vitro for immune tissue engineering are explored: tunable hydrogel platforms, decellularized tissues, and in-situ deposition of matrix by stromal cells. Overall, the challenge of recapitulating in vivo microenvironments is vast, but the inclusion of stromal cells in the study of extracellular matrix-immune cell dynamics is a vital step forward.

Indexed as

bone marrowextracellular matriximmunitylymph nodestromatissue engineering

Identifiers

PMID42488911
PMCPMC13390795

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.