ReviewFrontiers in bioengineering and biotechnology2026
Stem cell-derived extracellular vesicles for high-altitude skin injuries: pathological mechanisms, advanced Nano-delivery, and translational perspectives.
Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The extreme high-altitude environment-characterized by hypobaric hypoxia, intense ultraviolet radiation, and severe cold and aridity-imposes complex physical and biochemical stresses that synergistically drive pronounced cutaneous oxidative stress and barrier collapse. Given the limited capacity of conventional interventions to restore damaged cutaneous microenvironments, stem cell-derived extracellular vesicles (SC-EVs) have emerged as a promising cell-free regenerative modality for multitarget intervention. By delivering a diverse repertoire of bioactive molecules, SC-EVs concurrently help restore reactive oxygen species (ROS) homeostasis, attenuate inflammatory cascades, modulate angiogenesis, and mitigate extracellular matrix (ECM) degradation, thereby promoting coordinated restoration of cutaneous homeostasis. Nevertheless, the rapid
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