Evidence map›Paper›PMID 42488758›Full record

ArticleBrain communications2026

Substantia Nigra MRI markers are lower in Alzheimer's disease and are linked to general cognitive function.

Friedrich Krohn, Mousumi Sarkar, Hartmut Schütze, Panagiotis Iliopoulos, Lucía Penalba-Sánchez, Dorothea Hämmerer, Renat Yakupov, Falk Lüsebrink, Annika Spottke, Anja Schneider and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Friedrich KrohnInstitute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg 39120, Germany.ORCID https://orcid.org/0000-0001-8852-0753
Mousumi SarkarInstitute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg 39120, Germany.
Hartmut SchützeInstitute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg 39120, Germany.
Panagiotis IliopoulosInstitute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg 39120, Germany.
Lucía Penalba-SánchezInstitute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg 39120, Germany.
Dorothea HämmererInstitute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg 39120, Germany.
Renat YakupovInstitute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg 39120, Germany.ORCID https://orcid.org/0000-0002-3868-284X
Falk LüsebrinkInstitute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg 39120, Germany.
Annika SpottkeLeitung klinische Forschung, German Center for Neurodegenerative Diseases, Bonn 53127, Germany.
Anja SchneiderLeitung klinische Forschung, German Center for Neurodegenerative Diseases, Bonn 53127, Germany.
Nina RoyLeitung klinische Forschung, German Center for Neurodegenerative Diseases, Bonn 53127, Germany.
Enise IncesoyInstitute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg 39120, Germany.
Michael HenekaLeitung klinische Forschung, German Center for Neurodegenerative Diseases, Bonn 53127, Germany.ORCID https://orcid.org/0000-0003-4996-1630
Ingo KilimannKlinische Demenzforschung, German Center for Neurodegenerative Diseases, Rostock 18147, Germany.
Luca KleineidamLeitung klinische Forschung, German Center for Neurodegenerative Diseases, Bonn 53127, Germany.
Stefan J TeipelKlinische Demenzforschung, German Center for Neurodegenerative Diseases, Rostock 18147, Germany.
Frederic BrosseronLeitung klinische Forschung, German Center for Neurodegenerative Diseases, Bonn 53127, Germany.
Doreen GoerssLeitung klinische Forschung, German Center for Neurodegenerative Diseases, Bonn 53127, Germany.
Wenzel GlanzInstitute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg 39120, Germany.
Matthias SchmidInstitute for Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, Bonn 53127, Germany.
Ayda RostamzadehDepartment of Psychiatry, Medical Faculty, University of Cologne, Cologne 50924, Germany.
Michael WagnerLeitung klinische Forschung, German Center for Neurodegenerative Diseases, Bonn 53127, Germany.
Klaus FliessbachLeitung klinische Forschung, German Center for Neurodegenerative Diseases, Bonn 53127, Germany.
Frank Olaf JessenFaculty of Medicine, University of Cologne, Cologne 50932, Germany.
Emrah DüzelInstitute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg 39120, Germany.ORCID https://orcid.org/0000-0002-0139-5388
Matthew J BettsInstitute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg 39120, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individuals with Alzheimer's disease dementia show Alzheimer's disease pathology and a heterogeneous degeneration of the Substantia Nigra (SN) post-mortem. However, it is unclear how SN degeneration is related to cognitive dysfunction across the Alzheimer's disease dementia continuum. In this study, using data from the prospective DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE), we investigated whether

Indexed as

Alzheimer's diseasememoryneuromelaninnoveltySubstantia Nigra (SN)

Identifiers

PMID42488758
PMCPMC13390642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.